Human DIRAS1 Recombinant Protein (RPPB3353)
- SKU:
- RPPB3353
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O95057
Description
| Product Name: | Human DIRAS1 Recombinant Protein |
| Product Code: | RPPB3353 |
| Size: | 10µg |
| Species: | Human |
| Target: | DIRAS1 |
| Synonyms: | GTP-binding protein Di-Ras1, Distinct subgroup of the Ras family member 1, Ras-related inhibitor of cell growth, Rig, Small GTP-binding tumor suppressor 1, DIRAS1, GBTS1, Di-Ras1, FLJ42681. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | DIRAS1 Human solution (1mg/ml) containing 20mM Tris-HCl buffer(pH 8.0) containing 20% glycerol, 1mM DTT, 0.1M NaCl and 1mM EDTA. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MPEQSNDYRV VVFGAGGVGK SSLVLRFVKG TFRDTYIPTI EDTYRQVISC DKSVCTLQIT DTTGSHQFPA MQRLSISKGH AFILVFSVTS KQSLEELGPI YKLIVQIKGS VEDIPVMLVG KCDETQREV DTREAQAVAQ EWKCAFMETS AKMNYNVKEL FQELLTLETR RNMSLNIDGK RSGKQKRTDR KGKC |
DIRAS1 is a member of a distinct branch of the functionally diverse Ras superfamily of monomeric GTPases. DIRAS1 demonstrates low GTPase activity and exists mainly in the GTP-bound form. Ras proteins operate as binary molecular switches that control intracellular signaling networks. Ras-regulated signal pathways regulate such processes as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. Ras and ras-related proteins are frequently deregulated in cancers, leading to increased invasion and metastasis, and decreased apoptosis.
DIRAS1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 215 amino acids (1-195a.a.) and having a molecular mass of 24.1 kDa. DIRAS1 protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.
| UniProt Protein Function: | DIRAS1: Displays low GTPase activity and exist predominantly in the GTP-bound form. Belongs to the small GTPase superfamily. Di-Ras family.Protein type: G protein, monomeric, di-Ras; G protein; G protein, monomericChromosomal Location of Human Ortholog: 19p13.3Cellular Component: plasma membraneMolecular Function: GTP binding; GTPase activity; mitogen-activated protein kinase bindingBiological Process: positive regulation of MAP kinase activity |
| UniProt Protein Details: | |
| NCBI Summary: | DIRAS1 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004] |
| UniProt Code: | O95057 |
| NCBI GenInfo Identifier: | 62286591 |
| NCBI Gene ID: | 148252 |
| NCBI Accession: | O95057.1 |
| UniProt Secondary Accession: | O95057 |
| UniProt Related Accession: | O95057 |
| Molecular Weight: | 22,329 Da |
| NCBI Full Name: | GTP-binding protein Di-Ras1 |
| NCBI Synonym Full Names: | DIRAS family GTPase 1 |
| NCBI Official Symbol: | DIRAS1�� |
| NCBI Official Synonym Symbols: | RIG; GBTS1; Di-Ras1�� |
| NCBI Protein Information: | GTP-binding protein Di-Ras1 |
| UniProt Protein Name: | GTP-binding protein Di-Ras1 |
| UniProt Synonym Protein Names: | Distinct subgroup of the Ras family member 1; Ras-related inhibitor of cell growth; Rig; Small GTP-binding tumor suppressor 1 |
| Protein Family: | GTP-binding protein |
| UniProt Gene Name: | DIRAS1�� |
| UniProt Entry Name: | DIRA1_HUMAN |
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