Human DGCR6L Recombinant Protein (RPPB3352)
- SKU:
- RPPB3352
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9BY27
Description
| Product Name: | Human DGCR6L Recombinant Protein |
| Product Code: | RPPB3352 |
| Size: | 10µg |
| Species: | Human |
| Target: | DGCR6L |
| Synonyms: | Protein DGCR6L, DiGeorge syndrome critical region 6-like protein, DGCR6L. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | DGCR6L protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol, 1mM DTT and 250mM Imidazole. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMERYAAA LEEVADGARQ QERHYQLLSA LQSLVKELPS SFQQRLSYTT LSDLALALLD GTVFEIVQGL LEIQHLTEKS LYNQRLRLQN EHRVLRQALR QKHQEAQQAC RPHNLPVVQA AQQRELEAVE HRIREEQRAM DQKIILELDR KVADQQSTLE KAGVAGFYVT TNPQELMLQM NLLELIRKLQ QRGCRAGNAA LGLGGPWQSP AAQCDQKGSP VPP |
DiGeorge syndrome critical region 6-like protein (DGCR6L) shares homology with the Drosophila gonadal protein, it is expressed in gonadal tissues and germ cells, and with the human laminin gamma-1 chain which functions in cell attachment and migration. DGCR6L is located in a region of chromosome 22 involved in the DiGeorge syndrome, one aspect of a wider collection of anomalies referred to as the CATCH 22 syndrome. Moreover, it is one of two functional genes encoding nearly identical proteins which have analogous expression patterns.
DGCR6L Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 243 amino acids (1-220 a.a) and having a molecular mass of 27.3kDa.DGCR6L is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | DGCR6L: May play a role in neural crest cell migration into the third and fourth pharyngeal pouches. Belongs to the gonadal family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 22q11.21 Molecular Function:protein binding |
| NCBI Summary: | This gene, the result of a duplication at this locus, is one of two functional genes encoding nearly identical proteins that have similar expression patterns. The product of this gene is a protein that shares homology with the Drosophila gonadal protein, expressed in gonadal tissues and germ cells, and with the human laminin gamma-1 chain that functions in cell attachment and migration. This gene is located in a region of chromosome 22 implicated in the DiGeorge syndrome, one facet of a broader collection of anomalies referred to as the CATCH 22 syndrome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BY27 |
| NCBI GenInfo Identifier: | 22001579 |
| NCBI Gene ID: | 85359 |
| NCBI Accession: | Q9BY27.2 |
| UniProt Secondary Accession: | Q9BY27,Q9BW33, A8K1N7, B3KMC0, D3DX29, |
| UniProt Related Accession: | Q9BY27 |
| Molecular Weight: | 24,932 Da |
| NCBI Full Name: | Protein DGCR6L |
| NCBI Synonym Full Names: | DiGeorge syndrome critical region gene 6-like |
| NCBI Official Symbol: | DGCR6L�� |
| NCBI Official Synonym Symbols: | DGCR6�� |
| NCBI Protein Information: | protein DGCR6L |
| UniProt Protein Name: | Protein DGCR6L |
| UniProt Synonym Protein Names: | DiGeorge syndrome critical region 6-like protein |
| Protein Family: | Protein |
| UniProt Gene Name: | DGCR6L�� |
| UniProt Entry Name: | DGC6L_HUMAN |
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