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Human Deoxyribonuclease 1/DNASE1 Recombinant Protein (His tag) (RPES6029)

SKU:
RPES6029
Product Type:
Recombinant Protein
Species:
Human
€289

Description

Product Name:Human Deoxyribonuclease 1/DNASE1 Recombinant Protein (His tag)
Product Code:RPES6029
Size:20µg
Species:Human
Expression Host:HEK293 Cells
Synonyms:Deoxyribonuclease-1, EC 3.1.21.1, Deoxyribonuclease I, DNase I, Dornase alfa, DNASE1, DNL1, DRNI
Mol Mass:30.91 kDa
AP Mol Mass:40 kDa
Tag:C-His
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin Level:Please contact us for more information.
Bio Activity:Testing in progress
Sequence:Met 1-Lys282
Accession:P24855
Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution:Please refer to the printed manual for detailed information.
Background:DNase1, also known as deoxyribonuclease I and DNL1, is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. DNaseI binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. Mutations in DNase1 gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. DNase1 is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity.

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