Human DCT Recombinant Protein (RPPB1557)
- SKU:
- RPPB1557
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P40126
- Research Area:
- Enzymes
Description
| Product Name: | Human DCT Recombinant Protein |
| Product Code: | RPPB1557 |
| Size: | 10µg |
| Species: | Human |
| Target: | DCT |
| Synonyms: | L-dopachrome tautomerase (EC:5.3.3.12), DCT, DT, L-dopachromeDelta-isomerase Tyrosinase-related protein2, TRP-2, TRP2, TYRP2. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | STK3 protein solution (0.25mg/ml) containing PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | QFPRVCMTVD SLVNKECCPRLGAESANVCG SQQGRGQCTE VRADTRPWSG PYILRNQDDR ELWPRKFFHR TCKCTGNFAG YNCGDCKFGW TGPNCERKKP PVIRQNIHSL SPQEREQFLG ALDLAKKRVH PDYVITTQHW LGLLGPNGTQ PQFANCSVYDFFVWLHYYSV RDTLLGPGRP YRAIDFSHQG PAFVTWHRYH LLCLERDLQR LIGNESFALP YWNFATGRNECDVCTDQLFG AARPDDPTLI SRNSRFSSWE TVCDSLDDYN HLVTLCNGTY EGLLRRNQMG RNSMKLPTLK DIRDCLSLQK FDNPPFFQNS TFSFRNALEG FDKADGTLDS QVMSLHNLVH SFLNGTNALP HSAANDPIFVVLHSFTDAIF DEWMKRFNPP ADAWPQELAP IGHNRMYNMV PFFPPVTNEE LFLTSDQLGY SYAIDLPVSVEETPGWPTTH HHHHH |
Dopachrome Tautomerase also known as DCT,belongs to the tyrosinase family. DCT takes a significant part in the synthesisof the melanin pigment including tyrosinase (Tyr), tyrosinase-related protein 1(Tyrp1). Which are highly involved in eumelanin synthesis. The change among theeumelanin and the pheomelanin pathways is assumed to depend on the presence ofcysteine. Hence, in the lack of cysteine, dopaquinone, the product oftyrosinase action, is transformed to cyclodopa (leucodopachrome) and afterwardsto dopachrome (and DOPA).
DCT Human Recombinant produced in Sf9 Insect cell is asingle, non-glycosylated polypeptide chain containing 455 amino acids (24-472aa.a)and having a molecular mass of 52.1kDa (Migrates at 50-70kDa on SDS-PAGE underreducing conditions). DCT is fused to a 6 amino acidHis tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | DCT: Involved in regulating eumelanin and phaeomelanin levels. Belongs to the tyrosinase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 5.3.3.12; Cell development/differentiation; Membrane protein, integral; Isomerase; Amino Acid Metabolism - tyrosine Chromosomal Location of Human Ortholog: 13q32 Cellular Component: cytosol; melanosome; melanosome membrane Molecular Function:copper ion binding; dopachrome isomerase activity; oxidoreductase activity Biological Process: epidermis development; melanin biosynthetic process; melanin biosynthetic process from tyrosine |
| UniProt Code: | P40126 |
| NCBI GenInfo Identifier: | 731026 |
| NCBI Gene ID: | 1638 |
| NCBI Accession: | P40126.1 |
| UniProt Secondary Accession: | P40126,Q09GT4, |
| UniProt Related Accession: | P40126 |
| Molecular Weight: | 62,929 Da |
| NCBI Full Name: | L-dopachrome tautomerase |
| NCBI Synonym Full Names: | dopachrome tautomerase |
| NCBI Official Symbol: | DCT�� |
| NCBI Official Synonym Symbols: | TRP-2; TYRP2�� |
| NCBI Protein Information: | L-dopachrome tautomerase |
| UniProt Protein Name: | L-dopachrome tautomerase |
| UniProt Synonym Protein Names: | L-dopachrome Delta-isomerase; Tyrosinase-related protein 2; TRP-2; TRP2 |
| Protein Family: | dCTP deaminase |
| UniProt Gene Name: | DCT�� |
| UniProt Entry Name: | TYRP2_HUMAN |
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