Human Cyclophilin G Recombinant Protein (RPPB1545)
- SKU:
- RPPB1545
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q13427
- Research Area:
- Enzymes
Description
| Product Name: | Human Cyclophilin G Recombinant Protein |
| Product Code: | RPPB1545 |
| Size: | 25µg |
| Species: | Human |
| Target: | Cyclophilin G |
| Synonyms: | Peptidyl-prolyl cis-trans isomerase G, PPIase G, Rotamase G, PPIG, peptidylprolyl isomerase G, Cyclophilin G, Peptidyl-prolyl isomerase G, Rotamase G, Clk-associating RS-cyclophilin, CARS-cyclophilin, CARS-Cyp, SR-cyclophilin, SR-cyp, SRcyp, CASP10, CYP, MGC133241. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | Cyclophilin-G solution containing 20mM Tris-HCl pH-8, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGIKVQRPRC FFDIAINNQP AGRVVFELFS DVCPKTCENF RCLCTGEKGT GKSTQKPLHY KSCLFHRVVK DFMVQGGDFS EGNGRGGESI YGGFFEDESF AVKHNKEFLL SMANRGKDTN GSQFFITTKP TPHLDGHHVV FGQVISGQEV VREIENQKTD AASKPFAEVR ILSCG |
| Biological Activity: | Specific activity is > 200 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin. |
Cyclophilin-G is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and speeds up the protein folding. PPIG catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and is involved in the folding, transport, and assembly of proteins. PPIG is localized to the nuclear speckles, a nuclear compartment rich in splicing factors, and cooperates with the splicing factors SC35 and pinin. Cyclophilin-G also takes part in the regulation of pre-mRNA splicing.
Cyclophilin-G Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 195 amino acids (1-175 a.a.) and having a molecular mass of 21.6 kDa. Cyclophilin-G is fused to a 20 amino acid His Tag at N-terminus and is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PPIG: an ubiquitous peptidyl-prolyl cis/trans isomerase. Distributed in nuclear speckles, which are rich in splicing factors. Colocalizes with the splicing factor SFRS2. A component of splicing factor complexes that bind the phosphorylated C-terminal domain (CTD) of RNA polymerase II. Interacts with CLK1 and PNN. Two splice variant isoforms of the human protein have been described. |
| UniProt Protein Details: | Protein type:Isomerase; EC 5.2.1.8; Cyclophilin Chromosomal Location of Human Ortholog: 2q31.1 Cellular Component: nucleoplasm; nuclear matrix; cytoplasm; nuclear speck; nucleus Molecular Function:protein binding; peptidyl-prolyl cis-trans isomerase activity; cyclosporin A binding Biological Process: protein peptidyl-prolyl isomerization; protein folding; RNA splicing |
| UniProt Code: | Q13427 |
| NCBI GenInfo Identifier: | 229462749 |
| NCBI Gene ID: | 9360 |
| NCBI Accession: | Q13427.2 |
| UniProt Secondary Accession: | Q13427,O00706, Q53R40, Q53SN4, Q96DG9, D3DPC5, D3DPC6 |
| UniProt Related Accession: | Q13427 |
| Molecular Weight: | 754 |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase G |
| NCBI Synonym Full Names: | peptidylprolyl isomerase G (cyclophilin G) |
| NCBI Official Symbol: | PPIG�� |
| NCBI Official Synonym Symbols: | CYP; SRCyp; SCAF10; CARS-Cyp�� |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase G; CASP10; SR-cyp; PPIase G; rotamase G; cyclophilin G; SR-cyclophilin; CARS-cyclophilin; Clk-associating RS-cyclophilin; SR-related CTD-associated factor 10; peptidyl-prolyl isomerase G (cyclophilin G) |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase G |
| UniProt Synonym Protein Names: | CASP10; Clk-associating RS-cyclophilin; CARS-Cyp; CARS-cyclophilin; SR-cyclophilin; SR-cyp; SRcyp; Cyclophilin G; Rotamase G |
| Protein Family: | Cyprosin |
| UniProt Gene Name: | PPIG�� |
| UniProt Entry Name: | PPIG_HUMAN |
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