Human Cyclophilin B Recombinant Protein (RPPB1536)
- SKU:
- RPPB1536
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P23284
- Research Area:
- Enzymes
Description
| Product Name: | Human Cyclophilin B Recombinant Protein |
| Product Code: | RPPB1536 |
| Size: | 10µg |
| Species: | Human |
| Target: | Cyclophilin B |
| Synonyms: | Peptidylprolyl isomerase B, PPIase, Rotamase, S-cyclophilin, PPIB, cyclophilin-like protein, peptidyl-prolyl cis-trans isomerase B, Cyclophilin B, SCYLP, CYPB, CYP-S1, MGC2224, MGC14109. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Cyclophilin-B was filtered (0.4 �m) and lyophilized in 20mM Tris buffer and 50mM NaCl, pH 7.5. |
| Solubility: | It is recommended to add 200�l of deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Cyclophilin-B is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKHHHHHHAS DEKKKGPKVT VKVYFDLRIG DEDVGRVIFG LFGKTVPKTV DNFVALATGE KGFGYKNSKF HRVIKDFMIQ GGDFTRGDGT GGKSIYGERF PDENFKLKHY GPGWVSMANA GKDTNGSQFF ITTVKTAWLD GKHVVFGKVL EGMEVVRKVE STKTDSRDKP LKDVIIADCG KIEVEKPFAI AKE |
Cyclophilin B (also known as PPIB, peptidylpropyl isomerase B) is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression.
Cyclophilin-B Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Asp34-Glu216) containing 193 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 22kDa.
| UniProt Protein Function: | PPIB: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9). OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients. Belongs to the cyclophilin-type PPIase family. PPIase B subfamily. |
| UniProt Protein Details: | Protein type:Isomerase; Chaperone; EC 5.2.1.8; Secreted; Cyclophilin; Secreted, signal peptide; RNA-binding Chromosomal Location of Human Ortholog: 15q21-q22 Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; focal adhesion; melanosome; membrane; nucleus; perinuclear region of cytoplasm; smooth endoplasmic reticulum Molecular Function:collagen binding; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; protein complex binding; unfolded protein binding Biological Process: extracellular matrix organization and biogenesis; positive regulation of multicellular organism growth; protein peptidyl-prolyl isomerization; protein stabilization Disease: Osteogenesis Imperfecta, Type Ix |
| NCBI Summary: | The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009] |
| UniProt Code: | P23284 |
| NCBI GenInfo Identifier: | 215273869 |
| NCBI Gene ID: | 5479 |
| NCBI Accession: | P23284.2 |
| UniProt Secondary Accession: | P23284,Q6IBH5, Q9BVK5, A8K534, |
| UniProt Related Accession: | P23284 |
| Molecular Weight: | 23,743 Da |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase B |
| NCBI Synonym Full Names: | peptidylprolyl isomerase B |
| NCBI Official Symbol: | PPIB�� |
| NCBI Official Synonym Symbols: | OI9; CYPB; SCYLP; CYP-S1; HEL-S-39�� |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase B |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase B |
| UniProt Synonym Protein Names: | CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP |
| Protein Family: | Probable peptidyl-prolyl cis-trans isomerase |
| UniProt Gene Name: | PPIB�� |
| UniProt Entry Name: | PPIB_HUMAN |
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