Human Cyclophilin B Recombinant Protein (RPPB1535)
- SKU:
- RPPB1535
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P23284
- Research Area:
- Enzymes
Description
| Product Name: | Human Cyclophilin B Recombinant Protein |
| Product Code: | RPPB1535 |
| Size: | 50µg |
| Species: | Human |
| Target: | Cyclophilin B |
| Synonyms: | Peptidylprolyl isomerase B, PPIase, Rotamase, S-cyclophilin, PPIB, cyclophilin-like protein, peptidyl-prolyl cis-trans isomerase B, Cyclophilin B, SCYLP, CYPB, CYP-S1, MGC2224, MGC14109. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | 1 mg/ml solution containing 20mM Tris-HCl 8.0, 20mM NaCl, 0.5mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MLLPGPSAAD EKKKGPKVTV KVYFDLRIGD EDVGRVIFGL FGKTVPKTVD NFVALATGEKGFGYKNSKFH RVIKDFMIQG GDFTRGDGTG GKSIYGERFP DENFKLKHYG PGWVSMANAGKDTNGSQFFI TTVKTAWLDG KHVVFGKVLE GMEVVRKVES TKTDSRDKPL KDVIIADCGK IEVEKPFAIA KE |
| Biological Activity: | Specific activity is > 220 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin. |
Cyclophilin B (also known as PPIB, peptidylpropyl isomerase B) is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression.
Cyclophilin-B Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 192 amino acids (26-216) and having a molecular mass of 21.2 kDa. PPIB is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PPIB: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9). OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients. Belongs to the cyclophilin-type PPIase family. PPIase B subfamily. |
| UniProt Protein Details: | Protein type:Isomerase; Chaperone; EC 5.2.1.8; Secreted; Cyclophilin; Secreted, signal peptide; RNA-binding Chromosomal Location of Human Ortholog: 15q21-q22 Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; focal adhesion; melanosome; membrane; nucleus; perinuclear region of cytoplasm; smooth endoplasmic reticulum Molecular Function:collagen binding; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; protein complex binding; unfolded protein binding Biological Process: extracellular matrix organization and biogenesis; positive regulation of multicellular organism growth; protein peptidyl-prolyl isomerization; protein stabilization Disease: Osteogenesis Imperfecta, Type Ix |
| NCBI Summary: | The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009] |
| UniProt Code: | P23284 |
| NCBI GenInfo Identifier: | 215273869 |
| NCBI Gene ID: | 5479 |
| NCBI Accession: | P23284.2 |
| UniProt Secondary Accession: | P23284,Q6IBH5, Q9BVK5, A8K534, |
| UniProt Related Accession: | P23284 |
| Molecular Weight: | 23,743 Da |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase B |
| NCBI Synonym Full Names: | peptidylprolyl isomerase B |
| NCBI Official Symbol: | PPIB�� |
| NCBI Official Synonym Symbols: | OI9; CYPB; SCYLP; CYP-S1; HEL-S-39�� |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase B |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase B |
| UniProt Synonym Protein Names: | CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP |
| Protein Family: | Probable peptidyl-prolyl cis-trans isomerase |
| UniProt Gene Name: | PPIB�� |
| UniProt Entry Name: | PPIB_HUMAN |
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