Human CXCL16 Recombinant Protein (RPPB1113)
- SKU:
- RPPB1113
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9H2A7
- Research Area:
- Chemokines
Description
| Product Name: | Human CXCL16 Recombinant Protein |
| Product Code: | RPPB1113 |
| Size: | 25µg |
| Species: | Human |
| Target: | CXCL16 |
| Synonyms: | Chemokine (C-X-C Motif) Ligand 16, Scavenger Receptor For Phosphatidylserine And Oxidized Low Density Lipoprotein, Transmembrane Chemokine CXCL16, Small-Inducible Cytokine B16, CXC Chemokine Ligand 16, SR-PSOX, SRPSOX, C-X-C Motif Chemokine 16, CXCLG16, SCYB16, CXCL16. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | CXCL16 protein was lyophilized from a 0.2�m filtered solution in PBS. |
| Solubility: | It is recommended to reconstitute the lyophilized CXCL16 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized CXCL16 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL16 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | NEGSVTGSCY CGKRISSDSP PSVQFMNRLR KHLRAYHRCL YYTRFQLLSW SVCGGNKDPW VQELMSCLDL KECGHAYSGI VAHQKHLLP |
| Biological Activity: | The ED50, as measured by its ability to chemoattract mouse CXCR6-transfected mouse BaF3 cells, is less than 12ng/ml. |
CXC chemokine ligand 16 (CXCL16) is a type I membrane protein, which contains a non-ELR motif-containing CXC chemokine domain in its extracellular region. Human and Mouse CXCL16 share a 70% a.a. sequence similarity within their chemokine domains and 49% overall a.a. sequence identity. Functional CXCL16 can be dropped from the cell surface as an approximately 35kDa soluble protein. CXCR6 is the functional receptor for CXCL16. CXCL16 functions as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), proposing that CXCL16 may be involved in pathophysiology such as atherogenesis. In addition, CXCL16 induces a strong chemotactic response and calcium mobilization. CXCL16 binds to CXCR6/Bonzo.
CXCL16 Human Recombinant (30-118 a.a.) produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 89 amino acids and having a molecular mass of 10kDa.The CXCL16 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CXCL16: Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis. Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Belongs to the intercrine alpha (chemokine CxC) family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 17p13 Cellular Component: extracellular region; extracellular space; membrane Molecular Function:chemokine activity; low-density lipoprotein receptor activity; scavenger receptor activity Biological Process: positive regulation of cell growth; positive regulation of cell migration; response to cytokine stimulus |
| UniProt Code: | Q9H2A7 |
| NCBI GenInfo Identifier: | 209572770 |
| NCBI Gene ID: | 58191 |
| NCBI Accession: | Q9H2A7.4 |
| UniProt Secondary Accession: | Q9H2A7,Q8TC80, Q96K63, Q9BXD6, Q9H2F6, A0N0N4, A8K7U9 B2RCB0, |
| UniProt Related Accession: | Q9H2A7 |
| Molecular Weight: | 27,579 Da |
| NCBI Full Name: | C-X-C motif chemokine 16 |
| NCBI Synonym Full Names: | C-X-C motif chemokine ligand 16 |
| NCBI Official Symbol: | CXCL16�� |
| NCBI Official Synonym Symbols: | SRPSOX; CXCLG16; SR-PSOX�� |
| NCBI Protein Information: | C-X-C motif chemokine 16 |
| UniProt Protein Name: | C-X-C motif chemokine 16 |
| UniProt Synonym Protein Names: | Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein; SR-PSOX; Small-inducible cytokine B16; Transmembrane chemokine CXCL16 |
| Protein Family: | C-X-C motif chemokine |
| UniProt Gene Name: | CXCL16�� |
| UniProt Entry Name: | CXL16_HUMAN |
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