Human CTSE Recombinant Protein (RPPB1517)
- SKU:
- RPPB1517
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P14091
- Research Area:
- Enzymes
Description
| Product Name: | Human CTSE Recombinant Protein |
| Product Code: | RPPB1517 |
| Size: | 20µg |
| Species: | Human |
| Target: | CTSE |
| Synonyms: | CathepsinE, EC 3.4.23.34, CATE, Erythrocyte Membrane Aspartic Proteinase, Slow-MovingProteinase, EC 3.4.23. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | CTSE protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.4M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greaterthan 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSTESCSMD QSAKEPLINY LDMEYFGTIS IGSPPQNFTV IFDTGSSNLWVPSVYCTSPA CKTHSRFQPS QSSTYSQPGQ SFSIQYGTGS LSGIIGADQV SVEGLTVVGQ QFGESVTEPGQTFVDAEFDG ILGLGYPSLA VGGVTPVFDN MMAQNLVDLP MFSVYMSSNP EGGAGSELIF GGYDHSHFSG SLNWVPVTKQ AYWQIALDNMLWSVPTLTSC RMSPSPLTES PIPSAQLPTP YWTSWMECSS AAVAFKDLTS TLQLGPSGSW GMSSFDSFTQSLTVGITVWD WPQQSPKEGP CVCACLSDRP |
Cathepsin-E also known as CTSE is a gastric aspartyl protease whichfunctions as a disulfide-linked homodimer. CTSE belongs to the peptidase C1 family;furthermore it has specificity similar to pepsin A and cathepsin D. CTSE is anintracellular proteinase which does not seem to be involved in the digestion ofdietary protein and is found in theuppermost concentration in the surfaceof epithelial mucus-producing cells of the stomach. CTSE is the first aspartic proteinase expressed in the fetal stomach and is discovered in morethan half of gastric cancers. For that reason CTSE is an oncofetalantigen. In addition, transcript variants utilizing alternative polyadenylationsignals and two transcript variants encoding differentisoforms exist for this gene.
CTSE Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 330 amino acids (57-363 a.a) andhaving a molecular mass of 35.4kDa.CTSE is fused to a 23 amino acid His-tag atN-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CTSE: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. Belongs to the peptidase A1 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.23.34; Protease Chromosomal Location of Human Ortholog: 1q31 Cellular Component: endosome Molecular Function:protein homodimerization activity; aspartic-type endopeptidase activity Biological Process: protein autoprocessing; digestion; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis |
| NCBI Summary: | The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P14091 |
| NCBI GenInfo Identifier: | 46397366 |
| NCBI Gene ID: | 1510 |
| NCBI Accession: | P14091.2 |
| UniProt Secondary Accession: | P14091,Q5TZ01, Q5TZ02, Q9NY58, Q9UCE3, Q9UCE4, |
| UniProt Related Accession: | P14091 |
| Molecular Weight: | 396 |
| NCBI Full Name: | Cathepsin E |
| NCBI Synonym Full Names: | cathepsin E |
| NCBI Official Symbol: | CTSE�� |
| NCBI Official Synonym Symbols: | CATE�� |
| NCBI Protein Information: | cathepsin E; slow-moving proteinase; erythrocyte membrane aspartic proteinase |
| UniProt Protein Name: | Cathepsin E |
| Protein Family: | Cathepsin |
| UniProt Gene Name: | CTSE�� |
| UniProt Entry Name: | CATE_HUMAN |
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