Human CST7 Recombinant Protein (RPPB3294)
- SKU:
- RPPB3294
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O76096
Description
| Product Name: | Human CST7 Recombinant Protein |
| Product Code: | RPPB3294 |
| Size: | 10µg |
| Species: | Human |
| Target: | CST7 |
| Synonyms: | Cystatin-F, Cystatin-7, Cystatin-like metastasis-associated protein, CMAP, Leukocystatin, Cystatin 7, CST7, CMAP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The CST7 solution (0.5mg/1ml) contains phosphate buffered saline (pH7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | GPSPDTCSQD LNSRVKPGFP KTIKTNDPGV LQAARYSVEK FNNCTNDMFL FKESRITRAL VQIVKGLKYM LEVEIGRTTC KKNQHLRLDD CDFQTNHTLK QTLSCYSEVW VVPWLQHFEV PVLRCHHHHH HH |
Cystatin 7 (CST7) is a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. Cystatin-7 is comprised of multiple cystatin-like sequences. The superfamily is comprised of 3 inhibitory families: the type 1 cystatins (stefins), type 2 cystatins and the kininogens. Some members are active cysteine protease inhibitors, while others have lost or possibly never had this inhibitory activity. Type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in various human fluids and secretions. CST7 protein expression has been observed in numerous human cancer cell lines established from malignant tumors.
CST7 Human Recombinant produced in E. coli is a single polypeptide chain containing 132 amino acids (20-145) and having a molecular mass of 15.3kDa.CST7 is fused to a 7 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CST7: Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system. Belongs to the cystatin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 20p11.21 Cellular Component: cytoplasm; extracellular region Molecular Function:protein binding; endopeptidase inhibitor activity; cysteine protease inhibitor activity Biological Process: immune response |
| NCBI Summary: | The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. Expression of the protein has been observed in various human cancer cell lines established from malignant tumors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O76096 |
| NCBI GenInfo Identifier: | 262263314 |
| NCBI Gene ID: | 8530 |
| NCBI Accession: | |
| UniProt Secondary Accession: | O76096,Q6FH95, Q7Z4J8, Q9UED4, |
| UniProt Related Accession: | O76096 |
| Molecular Weight: | Calculated MW: 19kDaObserved MW: 19kDa |
| NCBI Full Name: | cystatin-F |
| NCBI Synonym Full Names: | cystatin F (leukocystatin) |
| NCBI Official Symbol: | CST7�� |
| NCBI Official Synonym Symbols: | CMAP�� |
| NCBI Protein Information: | cystatin-F; cystatin-7; cystatin-like metastasis-associated protein; leukocystatin |
| UniProt Protein Name: | Cystatin-F |
| UniProt Synonym Protein Names: | Cystatin-7; Cystatin-like metastasis-associated protein; CMAP; Leukocystatin |
| Protein Family: | Cystatin |
| UniProt Gene Name: | CST7�� |
| UniProt Entry Name: | CYTF_HUMAN |
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