Human CST1 Recombinant Protein (RPPB3279)
- SKU:
- RPPB3279
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P01037
Description
| Product Name: | Human CST1 Recombinant Protein |
| Product Code: | RPPB3279 |
| Size: | 20µg |
| Species: | Human |
| Target: | CST1 |
| Synonyms: | Cystatin-SN, Cystain-SA-I, Cystatin-1, Salivary cystatin-SA-1, CST1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CST1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 10% glycerol and 100mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMWSPKEE DRIIPGGIYN ADLNDEWVQR ALHFAISEYN KATKDDYYRR PLRVLRARQQ TVGGVNYFFD VEVGRTICTK SQPNLDTCAF HEQPELQKKQ LCSFEIYEVP WENRRSLVKS RCQES |
Cystatin-SN (CST1) belongs to the type 2 salivary cystatin family found in a variety of fluids and secretions, including plasma, tears, and saliva. The cystatin superfamily includes proteins which contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, whereas others have lost or possibly never developed this inhibitory activity. CST1 is up-regulated in cancerous lesions of gastric cancer tissues compared to noncancerous regions, in addition clinicopathological analysis revealed a significant correlation between high expression of CST1.
CST1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 145 amino acids (21-141 a.a.) and having a molecular mass of 16.9kDa. CST1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CST1: Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well. Belongs to the cystatin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 20p11.21 Cellular Component: extracellular space Molecular Function:cysteine protease inhibitor activity Biological Process: detection of chemical stimulus involved in sensory perception of bitter taste |
| NCBI Summary: | The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P01037 |
| NCBI GenInfo Identifier: | 311033460 |
| NCBI Gene ID: | 1469 |
| NCBI Accession: | P01037.3 |
| UniProt Secondary Accession: | P01037,Q96LE6, Q9UCQ6, |
| UniProt Related Accession: | P01037 |
| Molecular Weight: | 141 |
| NCBI Full Name: | Cystatin-SN |
| NCBI Synonym Full Names: | cystatin SN |
| NCBI Official Symbol: | CST1�� |
| NCBI Protein Information: | cystatin-SN; cystatin 1; cystatin-1; cystain-SA-I; cystatin SA-I; salivary cystatin-SA-1; cysteine proteinase inhibitor, type 2 family |
| UniProt Protein Name: | Cystatin-SN |
| UniProt Synonym Protein Names: | Cystain-SA-I; Cystatin-1; Salivary cystatin-SA-1 |
| Protein Family: | Cystatin |
| UniProt Gene Name: | CST1�� |
| UniProt Entry Name: | CYTN_HUMAN |
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