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Human CSRP2 Recombinant Protein (RPPB3278)

SKU:
RPPB3278
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q16527
€309
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Description

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Product Name:Human CSRP2 Recombinant Protein
Product Code:RPPB3278
Size:10µg
Species:Human
Target:CSRP2
Synonyms:Cysteine and glycine-rich protein 2, Smooth muscle cell LIM protein, LIM domain only 5 smooth muscle, SmLIM, LMO5, CRP2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The CSRP2 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMPVWGG GNKCGACGRT VYHAEEVQCD GRSFHRCCFL CMVCRKNLDS TTVAIHDEEI YCKSCYGKKY GPKGYGYGQG AGTLNMDRGE RLGIKPESVQ PHRPTTNPNT SKFAQKYGGA EKCSRCGDSV YAAEKIIGAG KPWHKNCFRC AKCGKSLEST TLTEKEGEIY CKGCYAKNFG PKGFGYGQGA GALVHAQ

CSRP2 belongs to the CSRP family. CSRP2 holds 2 LIM zinc-binding domains that take part in regulatory processes essential for development and cellular differentiation. Additionally, CSRP2 is involved in the development of the embryonic vascular system.

CSRP2 Human Recombinant produced in E. coli is a single polypeptide chain containing 217 amino acids (1-193) and having a molecular mass of 23.5kDa.CSRP2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CSRP2: a LIM protein that is differentially regulated and preferentially expressed in aortic smooth muscle cells. Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.
UniProt Protein Details:

Protein type:Cell development/differentiation

Chromosomal Location of Human Ortholog: 12q21.1

Cellular Component: focal adhesion; nucleus

Molecular Function:zinc ion binding

Biological Process: multicellular organismal development; cell differentiation

NCBI Summary:CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. [provided by RefSeq]
UniProt Code:Q16527
NCBI GenInfo Identifier:4503101
NCBI Gene ID:1466
NCBI Accession:NP_001312.1
UniProt Secondary Accession:Q16527,Q93030,
UniProt Related Accession:Q16527
Molecular Weight:20,954 Da
NCBI Full Name:cysteine and glycine-rich protein 2
NCBI Synonym Full Names:cysteine and glycine-rich protein 2
NCBI Official Symbol:CSRP2��
NCBI Official Synonym Symbols:CRP2; LMO5; SmLIM��
NCBI Protein Information:cysteine and glycine-rich protein 2; LMO-5; cysteine-rich protein 2; LIM domain only protein 5; smooth muscle cell LIM protein; LIM domain only 5, smooth muscle
UniProt Protein Name:Cysteine and glycine-rich protein 2
UniProt Synonym Protein Names:Cysteine-rich protein 2; CRP2; LIM domain only protein 5; LMO-5; Smooth muscle cell LIM protein
Protein Family:Cysteine and glycine-rich protein
UniProt Gene Name:CSRP2��
UniProt Entry Name:CSRP2_HUMAN

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