Human CRYZ Recombinant Protein (RPPB3274)
- SKU:
- RPPB3274
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q08257
Description
| Product Name: | Human CRYZ Recombinant Protein |
| Product Code: | RPPB3274 |
| Size: | 20µg |
| Species: | Human |
| Target: | CRYZ |
| Synonyms: | Quinone oxidoreductase, NADPH:quinone reductase, Zeta-crystallin, CRYZ, Quinone oxidoreductase isoform a, Crystallin, zeta (quinone reductase), Crystallin Zeta. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CRYZ protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMATGQKL MRAVRVFEFG GPEVLKLRSD IAVPIPKDHQ VLIKVHACGV NPVETYIRSG TYSRKPLLPY TPGSDVAGVI EAVGDNASAF KKGDRVFTSS TISGGYAEYA LAADHTVYKL PEKLDFKQGA AIGIPYFTAY RALIHSACVK AGESVLVHGA SGGVGLAACQ IARAYGLKIL GTAGTEEGQK IVLQNGAHEV FNHREVNYID KIKKYVGEKG IDIIIEMLAN VNLSKDLSLL SHGGRVIVVG SRGTIEINPR DTMAKESSII GVTLFSSTKE EFQQYAAALQ AGMEIGWLKP VIGSQYPLEK VAEAHENIIH GSGATGKMIL LL |
Crystallin Zeta, also known as CRYZ, Binds NADP and participates in a one-electron transfer process. CRYZ takes part in the detoxification of xenobiotics and Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. CRYZ improves the mRNA coding for BCL2.
CRYZ Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 352 amino acids (1-329 a.a.) and having a molecular mass of 37.6kDa.CRYZ is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CRYZ: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 1.6.5.5; Oxidoreductase; RNA-binding Chromosomal Location of Human Ortholog: 1p31.1 Cellular Component: cytoplasm; cytosol Molecular Function:mRNA 3'-UTR binding; NADPH:quinone reductase activity Biological Process: protein homotetramerization; visual perception; xenobiotic catabolic process |
| NCBI Summary: | Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008] |
| UniProt Code: | Q08257 |
| NCBI GenInfo Identifier: | 585013 |
| NCBI Gene ID: | 1429 |
| NCBI Accession: | Q08257.1 |
| UniProt Secondary Accession: | Q08257,Q53FT0, Q59EU7, Q5HYE7, Q6NSK9, A6NN60, D3DQ76 |
| UniProt Related Accession: | Q08257 |
| Molecular Weight: | 31,528 Da |
| NCBI Full Name: | Quinone oxidoreductase |
| NCBI Synonym Full Names: | crystallin zeta |
| NCBI Official Symbol: | CRYZ�� |
| NCBI Protein Information: | quinone oxidoreductase |
| UniProt Protein Name: | Quinone oxidoreductase |
| UniProt Synonym Protein Names: | NADPH:quinone reductase; Zeta-crystallin |
| Protein Family: | Zeta-crystallin |
| UniProt Gene Name: | CRYZ�� |
| UniProt Entry Name: | QOR_HUMAN |
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