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Human CRHBP Recombinant Protein (RPPB1269)

SKU:
RPPB1269
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P24387
Research Area:
Hormones
€309
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Description

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Product Name:Human CRHBP Recombinant Protein
Product Code:RPPB1269
Size:10µg
Species:Human
Target:CRHBP
Synonyms:Corticotropin releasing hormone binding protein, CRF-BP, CRH-BP, CRF-binding protein.
Source:Escherichia Coli
Physical Appearance:Filtered white lyophilized powder.
Formulation:CRHBP Human was filtered (0.4�m) and lyophilized from 0.5mg/ml supplied in 20mM TRIS and 20mM NaCl, pH 7.5.
Solubility:Add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -80°C for long term storage. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after one week at 4°C.
Amino Acid Sequence:MKHHHHHHAS YLELREAADY DPFLLFSANL KRELAGEQPY RRALRCLDML SLQGQFTFTA DRPQLHCAAF FISEPEEFIT IHYDQVSIDC QGGDFLKVFD GWILKGEKFP SSQDHPLPSA ERYIDFCESG LSRRSIRSSQ NVAMIFFRVH EPGNGFTLTI KTDPNLFPCN VISQTPNGKF TLVVPHQHRN CSFSIIYPVV IKISDLTLGH VNGLQLKKSS AGCEGIGDFV ELLGGTGLDP SKMTPLADLC YPFHGPAQMK VGCDNTVVRM VSSGKHVNRV TFEYRQLEPY ELENPNGNSI GEFCLSGL YLELREAADY DPFLLFSANL KRELAGEQPY RRALRCLDML SLQGQFTFTA DRPQLHCAAF FISEPEEFIT IHYDQVSIDC QGGDFLKVFD GWILKGEKFP SSQDHPLPSA ERYIDFCESG LSRRSIRSSQ NVAMIFFRVH EPGNGFTLTI KTDPNLFPCN VISQTPNGKF TLVVPHQHRN CSFSIIYPVV IKISDLTLGH VNGLQLKKSS AGCEGIGDFV ELLGGTGLDP SKMTPLADLC YPFHGPAQMK VGCDNTVVRM VSSGKHVNRV TFEYRQLEPY ELENPNGNSI GEFCLSGL

CRH is a powerful stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. CRH concentration in the human peripheral circulation is usually low. The concentration rises during pregnancy and fall back quickly after parturition. Maternal plasma CRH most likely originates from the placenta. Human plasma has a CRH-binding protein that inactivates CRH and can inhibit inappropriate pituitary-adrenal stimulation in pregnancy.

CRHBP Human Recombinant is a 34.58 kDa protein containing 308 aa and fused to a 10 aa N-Terminal His-tag. CRHBP is purified by proprietary chromatographic techniques.

UniProt Protein Function:CRHBP: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Inhibitor; Secreted

Chromosomal Location of Human Ortholog: 5q13.3

Cellular Component: dendrite; endoplasmic reticulum; extracellular space; Golgi apparatus; intracellular; microtubule; multivesicular body; nerve terminal; nucleus; perikaryon; secretory granule

Molecular Function:corticotropin-releasing hormone binding; peptide binding; protein binding

Biological Process: behavioral response to ethanol; cellular response to stress; female pregnancy; hormone-mediated signaling; inflammatory response; learning and/or memory; negative regulation of adrenocorticotropic hormone secretion; regulated secretory pathway; regulation of adrenocorticotropin hormone secretion; signal transduction; synaptic transmission, dopaminergic

NCBI Summary:Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]
UniProt Code:P24387
NCBI GenInfo Identifier:544099
NCBI Gene ID:1393
NCBI Accession:P24387.2
UniProt Secondary Accession:P24387,Q53F32, Q6FHT5,
UniProt Related Accession:P24387
Molecular Weight:36,144 Da
NCBI Full Name:Corticotropin-releasing factor-binding protein
NCBI Synonym Full Names:corticotropin releasing hormone binding protein
NCBI Official Symbol:CRHBP��
NCBI Official Synonym Symbols:CRFBP; CRF-BP��
NCBI Protein Information:corticotropin-releasing factor-binding protein
UniProt Protein Name:Corticotropin-releasing factor-binding protein
UniProt Synonym Protein Names:Corticotropin-releasing hormone-binding protein; CRH-BP
Protein Family:Corticotropin-releasing factor-binding protein
UniProt Gene Name:CRHBP��
UniProt Entry Name:CRHBP_HUMAN

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