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Human CREBZF Recombinant Protein (RPPB3248)

SKU:
RPPB3248
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NS37
€309
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Description

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Product Name:Human CREBZF Recombinant Protein
Product Code:RPPB3248
Size:10µg
Species:Human
Target:CREBZF
Synonyms:CREB/ATF BZIP Transcription Factor, Host CellFactor-Binding Transcription Factor Zhangfei, HCF-Binding Transcription FactorZhangfei, Zhangfei, ZF, SHP-Interacting Leucine Zipper Protein, SMILE, CREB/ATFbZIP transcription factor.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CREBZF protein solution (0.25mg/ml) containing PBS buffer(pH 7.4), 20% glycerol,1mM DTT and 0.1mM PMSF.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMRHSLTK LLAASGSNSP TRSESPEPAA TCSLPSDLTR AAAGEEETAAAGSPGRKQQF GDEGELEAGR GSRGGVAVRA PSPEEMEEEA IASLPGEETE DMDFLSGLEL ADLLDPRQPDWHLDPGLSSP GPLSSSGGGS DSGGLWRGDD DDEAAAAEMQRFSDLLQRLL NGIGGCSSSS DSGSAEKRRR KSPGGGGGGG SGNDNNQAATKSPRKAAAAA ARLNRLKKKE YVMGLESRVR GLAAENQELR AENRELGKRV QALQEESRYL RAVLANETGLARLLSRLSGV GLRLTTSLFR DSPAGDHDYA LPVGKQKQDL LEEDDSAGGV CLHVDKDKVSVEFCSACARK ASSSLKM

CREB/ATF BZIP Transcription Factor, also known as CREBZF activatestranscription strongly once bound to HCFC1. CREBZF suppresses the expression ofHSV proteins in cells infected with the virus in a HCFC1-dependent manner.� CREBZF suppresses the HCFC1-dependenttranscriptional activation through CREB3 and reduces the quantity of CREB3 inthe cell. In addition, CREBZF is capable to down-regulate expression of a fewcellular genes in CREBZF-expressing cells.

CREBZF Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 377 amino acids (1-354 a.a) andhaving a molecular mass of 39.5kDa.�CREBZF is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:CREBZF: Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1- dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. Belongs to the bZIP family. ATF subfamily.
UniProt Protein Details:

Protein type:Transcription factor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 11q14

Cellular Component: nucleus

Molecular Function:identical protein binding; protein binding

Biological Process: negative regulation of gene expression, epigenetic; negative regulation of transcription, DNA-dependent; regulation of transcription factor activity; response to virus; transcription, DNA-dependent

UniProt Code:Q9NS37
NCBI GenInfo Identifier:251757415
NCBI Gene ID:58487
NCBI Accession:Q9NS37.2
UniProt Secondary Accession:Q9NS37,Q0P5U9, Q52LT3, B2R8Q9,
UniProt Related Accession:Q9NS37
Molecular Weight:37,134 Da
NCBI Full Name:CREB/ATF bZIP transcription factor
NCBI Synonym Full Names:CREB/ATF bZIP transcription factor
NCBI Official Symbol:CREBZF��
NCBI Official Synonym Symbols:ZF; SMILE��
NCBI Protein Information:CREB/ATF bZIP transcription factor
UniProt Protein Name:CREB/ATF bZIP transcription factor
UniProt Synonym Protein Names:Host cell factor-binding transcription factor Zhangfei; HCF-binding transcription factor Zhangfei
Protein Family:CREB/ATF bZIP transcription factor
UniProt Gene Name:CREBZF��
UniProt Entry Name:ZHANG_HUMAN

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