Human CPLX1 Recombinant Protein (RPPB3240)
- SKU:
- RPPB3240
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O14810
Description
| Product Name: | Human CPLX1 Recombinant Protein |
| Product Code: | RPPB3240 |
| Size: | 50µg |
| Species: | Human |
| Target: | CPLX1 |
| Synonyms: | CPLX-1, CPXI, CPX-I, CPX1, CPX-1, Synaphin2, Synaphin-2, Complexin-1, Complexin I, CPX I, CPLX1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CPLX1protein solution contains 20mM Tris-HCl pH-8 and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MEFVMKQALG GATKDMGKML GGDEEKDPDA AKKEEERQEA LRQAEEERKA KYAKMEAERE AVRQGIRDKYGIKKKEEREA EAQAAMEANS EGSLTRPKKA IPPGCGDEVE EEDESILDTV IKYLPGPLQD MLKK |
CPLX1 is part of the SNARE family complex binding proteins that are catalysts or inhibitors of vesicle exocytosis. CPLX1 shows reduced Ca2+-triggered fast neurotransmitter release at hippocampal glutamatergic synapses, indicating that CPLX1 is a positive regulator of transmitter release. In contrast, CPLX1 inhibits SNARE-mediated liposome and cell fusions in vitro, that result in hypothesis thus acts as a fusion clamp of synaptic exocytosis. CPLX1 regulates a late step in synaptic vesicle exocytosis.�
CPLX1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 154 amino acids (1-134 a.a) and having a molecular mass of 17.1kDa (molecular weight on SDS-PAGE will appear higher).The CPLX1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CPLX1: Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Belongs to the complexin/synaphin family. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 4p16.3 Cellular Component: cytosol Biological Process: exocytosis; glutamate secretion; neurotransmitter secretion; regulation of exocytosis; synaptic transmission Disease: Wolf-hirschhorn Syndrome |
| NCBI Summary: | Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14810 |
| NCBI GenInfo Identifier: | 5921800 |
| NCBI Gene ID: | 10815 |
| NCBI Accession: | O14810.1 |
| UniProt Secondary Accession: | O14810,A6NI80, B2R4R5, D3DVN3, F1T0G1, |
| UniProt Related Accession: | O14810 |
| Molecular Weight: | 15kDa |
| NCBI Full Name: | Complexin-1 |
| NCBI Synonym Full Names: | complexin 1 |
| NCBI Official Symbol: | CPLX1�� |
| NCBI Official Synonym Symbols: | CPX1; CPX-I�� |
| NCBI Protein Information: | complexin-1 |
| UniProt Protein Name: | Complexin-1 |
| UniProt Synonym Protein Names: | Complexin I; CPX I; Synaphin-2 |
| UniProt Gene Name: | CPLX1�� |
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