Human COPS8 Recombinant Protein (RPPB3232)
- SKU:
- RPPB3232
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q99627
Description
| Product Name: | Human COPS8 Recombinant Protein |
| Product Code: | RPPB3232 |
| Size: | 20µg |
| Species: | Human |
| Target: | COPS8 |
| Synonyms: | COP9 signalosome complex subunit 8, SGN8, Signalosome subunit 8, COP9 homolog, hCOP9, JAB1-containing signalosome subunit 8, COPS8, CSN8, COP9. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The COPS8 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MPVAVMAESA FSFKKLLDQC ENQELEAPGG IATPPVYGQL LALYLLHNDM NNARYLWKRI PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE TVQPIMEALR DATRRRAFAL VSQAYTSIIA DDFAAFVGLP VEEAVKGILE QGWQADSTTR MVLPRKPVAG ALDVSFNKFI PLSEPAPVPP IPNEQQLARL TDYVAFLEN |
COP9 signalosome complex subunit 8 isoform 1 (COPS8) is one of the 8 subunits of COP9 signalosome, which is a much conserved protein complex that functions as an imperative regulator in multiple signaling pathways. The structure and function of COP9 signalosome is analogous to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome interacts with SCF-type E3 ubiquitin ligases and acts as a positive regulator of E3 ubiquitin ligases.
COPS8 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 229 amino acids (1-209) and having a molecular mass of 25.3kDa.COPS8 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | COPS8: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Belongs to the CSN8 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: cytosol; nucleoplasm; nucleus; perinuclear region of cytoplasm; signalosome Molecular Function:protein binding Biological Process: activation of NF-kappaB-inducing kinase; negative regulation of cell proliferation; nucleotide-excision repair, DNA damage recognition; protein deneddylation; transcription-coupled nucleotide-excision repair |
| NCBI Summary: | The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99627 |
| NCBI GenInfo Identifier: | 55976572 |
| NCBI Gene ID: | 10920 |
| NCBI Accession: | Q99627.1 |
| UniProt Secondary Accession: | Q99627,Q53QS9, A8K1H6, |
| UniProt Related Accession: | Q99627 |
| Molecular Weight: | 23kDa |
| NCBI Full Name: | COP9 signalosome complex subunit 8 |
| NCBI Synonym Full Names: | COP9 signalosome subunit 8 |
| NCBI Official Symbol: | COPS8�� |
| NCBI Official Synonym Symbols: | COP9; CSN8; SGN8�� |
| NCBI Protein Information: | COP9 signalosome complex subunit 8 |
| UniProt Protein Name: | COP9 signalosome complex subunit 8 |
| UniProt Synonym Protein Names: | COP9 homolog; hCOP9; JAB1-containing signalosome subunit 8 |
| UniProt Gene Name: | COPS8�� |
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