Human COPE Recombinant Protein (RPPB3238)
- SKU:
- RPPB3238
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O14579
Description
| Product Name: | Human COPE Recombinant Protein |
| Product Code: | RPPB3238 |
| Size: | 10µg |
| Species: | Human |
| Target: | COPE |
| Synonyms: | Coatomer Protein Complex, Subunit Epsilon, Epsilon-CoatProtein, Epsilon-COP, Coatomer Epsilon Subunit, Coatomer Subunit Epsilon, EpsilonCoat Protein, Coatomer subunit epsilon. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | COPE protein solution (0.25 mg/ml) containing Phosphatebuffered saline (pH7.4),20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAPPAPG PASGGSGEVD ELFDVKNAFY IGSYQQCINE AQRVKLSSPERDVERDVFLY RAYLAQRKFG VVLDEIKPSS APELQAVRMF ADYLAHESRR DSIVAELDRE MSRSVDVTNTTFLLMAASIY LHDQNPDAAL RALHQGDSLE CTAMTVQILLKLDRLDLARK ELKRMQDLDE DATLTQLATA WVSLATGGEK LQDAYYIFQEMADKCSPTLL LLNGQAACHM AQGRWEAAEG LLQEALDKDS GYPETLVNLI VLSQHLGKPP EVTNRYLSQLKDAHRSHPFI KEYQAKENDF DRLVLQYAPS A |
Coatomer Protein Complex Subunit Epsilon, also known as COPE is an epsilon subunit ofcoatomer protein complex. Coatomer is a cytosolic protein complex which binds� to dilysine motifsand reversibly links with Golgi�non-clathrin-coated vesicles. COPE is necessary for buddingfrom Golgi membranes, and is also essential for the retrograde Golgi-to-ERtransport of dilysine-tagged proteins. Coatomercomplex contain at least the alpha, beta, beta', gamma, delta, epsilon and zetasubunits. �Alternatively spliced transcript variantsencoding dissimilar isoforms have been identified forCOPE.
COPE Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 331 amino acids (1-308 a.a) andhaving a molecular mass of 36.9kDa.COPE is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | COPE: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Belongs to the COPE family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: COPI vesicle coat; cytosol; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; nucleoplasm; transport vesicle Molecular Function:protein binding Biological Process: ER to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to ER |
| NCBI Summary: | The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14579 |
| NCBI GenInfo Identifier: | 6647482 |
| NCBI Gene ID: | 11316 |
| NCBI Accession: | O14579.3 |
| UniProt Secondary Accession: | O14579,O76097, Q6IBB8, Q9UGP6, A6NE29, A6NKA3, |
| UniProt Related Accession: | O14579 |
| Molecular Weight: | 28,773 Da |
| NCBI Full Name: | Coatomer subunit epsilon |
| NCBI Synonym Full Names: | coatomer protein complex subunit epsilon |
| NCBI Official Symbol: | COPE�� |
| NCBI Official Synonym Symbols: | epsilon-COP�� |
| NCBI Protein Information: | coatomer subunit epsilon |
| UniProt Protein Name: | Coatomer subunit epsilon |
| UniProt Synonym Protein Names: | Epsilon-coat protein; Epsilon-COP |
| Protein Family: | Coatomer |
| UniProt Gene Name: | COPE�� |
| UniProt Entry Name: | COPE_HUMAN |
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