Human COMMD1 Recombinant Protein (RPPB3226)
- SKU:
- RPPB3226
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8N668
Description
| Product Name: | Human COMMD1 Recombinant Protein |
| Product Code: | RPPB3226 |
| Size: | 10µg |
| Species: | Human |
| Target: | COMMD1 |
| Synonyms: | MURR1, C2orf5, COMMD1, Copper Metabolism Domain Containing 1, MGC27155. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | COMMD1 Human solution containing 20mM Tris pH-8, 0.1M NaCl & 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAAGELEGGK PLSGLLNALA QDTFHGYPGI TEELLRSQLY PEVPPEEFRP FLAKMRGILK SIASADMDFN QLEAFLTAQT KKQGGITSDQ AAVISKFWKS HKTKIRESLM NQSRWNSGLR GLSWRVDGKS QSRHSAQIHT PVAIIELELG KYGQESEFLC LEFDEVKVNQ ILKTLSEVEE SISTLISQPN |
COMMD1 is accountable for inhibition of TNF-induced NF?B p50 and n facilitats of biliary copper excretion within hepatocytes. High expression of COMMD1 is localized in liver tissue, with lower expressions in lung, heart, kidney and brain tissue. COMMD1 interacts directly with COMMD6 and ATP7B, and indirectly with I?B-Beta and COMMD7.
COMMD1 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 210 amino acids (1-190 a.a.) and having a molecular mass of 23.3 kDa. The COMMD1 is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | COMMD1: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. |
| UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 2p15 Cellular Component: Cul2-RING ubiquitin ligase complex; cytoplasm; cytoplasmic membrane-bound vesicle; early endosome; endosome membrane; nucleoplasm; nucleus; recycling endosome Molecular Function:copper ion binding; identical protein binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein homodimerization activity Biological Process: copper ion homeostasis; Golgi to plasma membrane transport; inhibition of NF-kappaB transcription factor; plasma membrane to endosome transport; positive regulation of protein ubiquitination; protein transport; regulation of proteasomal ubiquitin-dependent protein catabolic process; transcription, DNA-dependent |
| NCBI Summary: | COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009] |
| UniProt Code: | Q8N668 |
| NCBI GenInfo Identifier: | 51316026 |
| NCBI Gene ID: | 150684 |
| NCBI Accession: | Q8N668.1 |
| UniProt Secondary Accession: | Q8N668,Q96GS0, B4DFQ4, |
| UniProt Related Accession: | Q8N668 |
| Molecular Weight: | 17,665 Da |
| NCBI Full Name: | COMM domain-containing protein 1 |
| NCBI Synonym Full Names: | copper metabolism domain containing 1 |
| NCBI Official Symbol: | COMMD1�� |
| NCBI Official Synonym Symbols: | MURR1; C2orf5�� |
| NCBI Protein Information: | COMM domain-containing protein 1 |
| UniProt Protein Name: | COMM domain-containing protein 1 |
| UniProt Synonym Protein Names: | Protein Murr1 |
| Protein Family: | COMM domain-containing protein |
| UniProt Gene Name: | COMMD1�� |
| UniProt Entry Name: | COMD1_HUMAN |
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