Human CNPY3 Recombinant Protein (RPPB3217)
- SKU:
- RPPB3217
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9BT09
Description
| Product Name: | Human CNPY3 Recombinant Protein |
| Product Code: | RPPB3217 |
| Size: | 20µg |
| Species: | Human |
| Target: | CNPY3 |
| Synonyms: | CAG4A, ERDA5, PRAT4A, TNRC5, Protein canopy homolog 3, CTG repeat protein 4a, Expanded repeat-domain protein CAG/CTG 5, Protein associated with TLR4, Trinucleotide repeat-containing gene 5 protein,CNPY3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CNPY3 protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSGPSQAGA EENDWVRLPS KCEVCKYVAV ELKSAFEETG KTKEVIGTGY GILDQKASGV KYTKSDLRLI EVTETICKRL LDYSLHKERT GSNRFAKGMS ETFETLHNLV HKGVKVVMDI PYELWNETSA EVADLKKQCD VLVEEFEEVI EDWYRNHQEE DLTEFLCANH VLKGKDTSCL AEQWSGKKGD TAALGGKKSK KKSSRAKAAG GRSSSSKQRK ELGGLEGDPS PEEDEGIQKA SPLTHSPPDE L |
Canopy 3 homolog (CNPY3) is a 271 a.aToll-like receptor specific co-chaperone for HSP90B1. CNPY3 is necessitated for proper TLR folding, excluding that of TLR3, and so controls TLR exit from the endoplasmic reticulum. Therefore, CNPY3i s required for both innate and adaptive immune responses.
CNPY3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 271 amino acids (31-278 a.a.) and having a molecular mass of 29.9kDa. CNPY3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TNRC5: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptative immune responses. Belongs to the canopy family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: endoplasmic reticulum lumen Molecular Function:receptor binding Biological Process: toll-like receptor signaling pathway; innate immune response |
| NCBI Summary: | This gene encodes a protein that binds members of the toll-like receptor protein family and functions as a chaperone to aid in folding and export of these proteins. Alternative splicing results in multiple transcript variants. Naturally occuring readthrough transcription occurs between this locus and the downstream GNMT (glycine N-methyltransferase) gene and is represented with GeneID:107080644. [provided by RefSeq, Jan 2016] |
| UniProt Code: | Q9BT09 |
| NCBI GenInfo Identifier: | 74752319 |
| NCBI Gene ID: | 10695 |
| NCBI Accession: | Q9BT09.1 |
| UniProt Related Accession: | Q9BT09 |
| Molecular Weight: | |
| NCBI Full Name: | Protein canopy homolog 3 |
| NCBI Synonym Full Names: | canopy FGF signaling regulator 3 |
| NCBI Official Symbol: | CNPY3�� |
| NCBI Official Synonym Symbols: | CAG4A; ERDA5; TNRC5; EIEE60; PRAT4A�� |
| NCBI Protein Information: | protein canopy homolog 3 |
| UniProt Protein Name: | Protein canopy homolog 3 |
| UniProt Synonym Protein Names: | CTG repeat protein 4a; Expanded repeat-domain protein CAG/CTG 5; Protein associated with TLR4; Trinucleotide repeat-containing gene 5 protein |
| Protein Family: | Protein canopy |
| UniProt Gene Name: | CNPY3�� |
| UniProt Entry Name: | CNPY3_HUMAN |
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