Human CNDP2 Recombinant Protein (RPPB1501)
- SKU:
- RPPB1501
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96KP4
- Research Area:
- Enzymes
Description
| Product Name: | Human CNDP2 Recombinant Protein |
| Product Code: | RPPB1501 |
| Size: | 20µg |
| Species: | Human |
| Target: | CNDP2 |
| Synonyms: | Cytosolic non-specific dipeptidase, CNDP dipeptidase 2, CN2, CPGL, HsT2298, PEPA, Glutamate carboxypeptidase-like protein 1, Peptidase A. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CNDP2 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAALTTL FKYIDENQDR YIKKLAKWVA IQSVSAWPEK RGEIRRMMEV AAADVKQLGG SVELVDIGKQ KLPDGSEIPL PPILLGRLGS DPQKKTVCIY GHLDVQPAAL EDGWDSEPFT LVERDGKLYG RGSTDDKGPV AGWINALEAY QKTGQEIPVN VRFCLEGMEE SGSEGLDELI FARKDTFFKD VDYVCISDNY WLGKKKPCIT YGLRGICYFF IEVECSNKDL HSGVYGGSVH EAMTDLILLM GSLVDKRGNI LIPGINEAVA AVTEEEHKLY DDIDFDIEEF AKDVGAQILL HSHKKDILMH RWRYPSLSLH GIEGAFSGSG AKTVIPRKVV GKFSIRLVPN MTPEVVGEQV TSYLTKKFAE LRSPNEFKVY MGHGGKPWVS DFSHPHYLAG RRAMKTVFGV EPDLTREGGS IPVTLTFQEA TGKNVMLLPV GSADDGAHSQ NEKLNRYNYI EGTKMLAAYL YEVSQLKD |
CNDP Dipeptidase 2 (CNDP2), is a cytosolic, non-specific dipeptidase which is a part of the peptidase M20A protein family. CNDP2 is a secreted peptidase homologous to M20 peptidases. CNDP2 expresses through all adult and fetal tissue, though, an isoform missing exons 3 and 4 expresses in all fetal tissue in adult liver. Over expression of CPGL-B in hepatocellular carcinoma cells results in significant inhibition of HC cell viability, colony formation, cell invasiveness and tumor configuration.
CNDP2 Human Recombinant produced in E. coli is a single polypeptide chain containing 498 amino acids (1-475) and having a molecular mass of 55.3 kDa. CNDP2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CNDP2: Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Belongs to the peptidase M20A family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.13.18; Protease Chromosomal Location of Human Ortholog: 18q22.3 Cellular Component: cytosol; nucleoplasm Molecular Function:carboxypeptidase activity Biological Process: glutathione biosynthetic process; sulfur amino acid metabolic process |
| NCBI Summary: | CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q96KP4 |
| NCBI GenInfo Identifier: | 23396498 |
| NCBI Gene ID: | 55748 |
| NCBI Accession: | Q96KP4.2 |
| UniProt Secondary Accession: | Q96KP4,Q8WY59, Q9BQ94, Q9NVB4, B3KUG4, V9HWE5, |
| UniProt Related Accession: | Q96KP4 |
| Molecular Weight: | 53kDa |
| NCBI Full Name: | Cytosolic non-specific dipeptidase |
| NCBI Synonym Full Names: | carnosine dipeptidase 2 |
| NCBI Official Symbol: | CNDP2�� |
| NCBI Official Synonym Symbols: | CN2; CPGL; PEPA; HsT2298; HEL-S-13�� |
| NCBI Protein Information: | cytosolic non-specific dipeptidase |
| UniProt Protein Name: | Cytosolic non-specific dipeptidase |
| UniProt Synonym Protein Names: | CNDP dipeptidase 2; Carnosine dipeptidase II |
| Protein Family: | Cytosolic non-specific dipeptidase |
| UniProt Gene Name: | CNDP2�� |
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