Human CLEC4E Recombinant Protein (RPPB3197)
- SKU:
- RPPB3197
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9ULY5
Description
| Product Name: | Human CLEC4E Recombinant Protein |
| Product Code: | RPPB3197 |
| Size: | 20µg |
| Species: | Human |
| Target: | CLEC4E |
| Synonyms: | C-TypeLectin Domain Family 4, Member E, MINCLE, C-Type (Calcium Dependent,Carbohydrate-Recognition Domain) Lectin, Superfamily Member 9, Macrophage-InducibleC-Type Lectin, C-Type Lectin Superfamily Member 9, CLECSF9, C-Type LectinDomain Family 4 Member E, C-type lectin domain family 4 member E. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CLEC4Eprotein solution (0.25mg/ml) containing 20mM Tris 8.0 and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHHSSGLVPRGSH MRCVVTFRIFQTCDEKKFQL PENFTELSCY NYGSGSVKNC CPLNWEYFQS SCYFFSTDTI SWALSLKNCS AMGAHLVVINSQEEQEFLSY KKPKMREFFI GLSDQVVEGQ WQWVDGTPLT KSLSFWDVGE PNNIATLEDC ATMRDSSNPRQNWNDVTCFL NYFRICEMVG INPLNKGKSL |
C-type lectin domain family 4, member E, also known as CLEC4E is a C-type lectin receptor expressed through a wide range of antigens which presents cells including macrophages, neutrophils, dendritic cells as well as B cells; Furthermore, a variety of stimuli including stress are acknowledged to induce the expression of CLEC4E.
CLEC4E Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 200 amino acids (41-219 a.a) and having amolecular mass of 22.9kDa.CLEC4E is fused to a 21 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CLEC4E: C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 12p13.31 Cellular Component: integral to membrane; plasma membrane Molecular Function:carbohydrate binding; receptor activity Biological Process: defense response to bacterium; innate immune response; positive regulation of cytokine secretion; stimulatory C-type lectin receptor signaling pathway; T cell differentiation during immune response |
| NCBI Summary: | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9ULY5 |
| NCBI GenInfo Identifier: | 7657333 |
| NCBI Gene ID: | 26253 |
| NCBI Accession: | NP_055173.1 |
| UniProt Secondary Accession: | Q9ULY5,B2R6Q6, |
| UniProt Related Accession: | Q9ULY5 |
| Molecular Weight: | 25,073 Da |
| NCBI Full Name: | C-type lectin domain family 4 member E |
| NCBI Synonym Full Names: | C-type lectin domain family 4 member E |
| NCBI Official Symbol: | CLEC4E�� |
| NCBI Official Synonym Symbols: | MINCLE; CLECSF9�� |
| NCBI Protein Information: | C-type lectin domain family 4 member E |
| UniProt Protein Name: | C-type lectin domain family 4 member E |
| UniProt Synonym Protein Names: | C-type lectin superfamily member 9; Macrophage-inducible C-type lectin |
| Protein Family: | C-type lectin domain family |
| UniProt Gene Name: | CLEC4E�� |
| UniProt Entry Name: | CLC4E_HUMAN |
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