Human CLEC1B Recombinant Protein (RPPB3192)
- SKU:
- RPPB3192
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9P126
Description
| Product Name: | Human CLEC1B Recombinant Protein |
| Product Code: | RPPB3192 |
| Size: | 20µg |
| Species: | Human |
| Target: | CLEC1B |
| Synonyms: | C-Type Lectin Domain Family 1, Member B, CLEC2, C-TypeLectin-Like Receptor 2, CLEC2B, CLEC-2, C-Type Lectin Domain Family 1 Member B,C-Type Lectin-Like Receptor-2, 1810061I13Rik, PRO1384, QDED721, C-type lectindomain family 1 member B, C-type lectin-like receptor 2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CLEC1B protein solution (1mg/ml) containing 20mM Tris, PH8.0 and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSSVMQRNY LQGENENRTG TLQQLAKRFC QYVVKQSELK GTFKGHKCSPCDTNWRYYGD SCYGFFRHNL TWEESKQYCT DMNATLLKID NRNIVEYIKA RTHLIRWVGL SRQKSNEVWKWEDGSVISEN MFEFLEDGKG NMNCAYFHNG KMHPTFCENK HYLMCERKAG MTKVDQLP |
C-typeLectin Domain Family 1 Member B, also known as CLEC1B. NK-Natural killer cellsexpress multiple calcium-dependent (C-type) lectin-like receptors, for instanceCD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), which interact withmajor histocompatibility complex class I molecules and either inhibit or elseactivate cytotoxicity and cytokine secretion. CLEC1B is a C-type lectin-likereceptor which is expressed in myeloid cells as well as in NK cells.
CLEC1B Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 198 amino acids (55-229 a.a) and having amolecular mass of 23.1kDa.CLEC1B is fused to a 23amino acid His-tag at N-terminus & purified by proprietary chromatographictechniques.
| UniProt Protein Function: | CLEC1B: Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 12p13.2 Cellular Component: integral to plasma membrane Molecular Function:protein binding; transmembrane receptor activity; carbohydrate binding Biological Process: cell surface receptor linked signal transduction; defense response; platelet formation |
| NCBI Summary: | Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011] |
| UniProt Code: | Q9P126 |
| NCBI GenInfo Identifier: | 134035066 |
| NCBI Gene ID: | 51266 |
| NCBI Accession: | Q9P126.2 |
| UniProt Secondary Accession: | Q9P126,Q6UWX7, Q8NHR6, |
| UniProt Related Accession: | Q9P126 |
| Molecular Weight: | 23,096 Da |
| NCBI Full Name: | C-type lectin domain family 1 member B |
| NCBI Synonym Full Names: | C-type lectin domain family 1, member B |
| NCBI Official Symbol: | CLEC1B�� |
| NCBI Official Synonym Symbols: | CLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik�� |
| NCBI Protein Information: | C-type lectin domain family 1 member B; CLEC-2; C-type lectin-like receptor 2; C-type lectin-like receptor-2 |
| UniProt Protein Name: | C-type lectin domain family 1 member B |
| UniProt Synonym Protein Names: | C-type lectin-like receptor 2; CLEC-2 |
| Protein Family: | C-type lectin domain family |
| UniProt Gene Name: | CLEC1B�� |
| UniProt Entry Name: | CLC1B_HUMAN |
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