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Human CINP Recombinant Protein (RPPB2472)

SKU:
RPPB2472
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9BW66
Research Area:
Enzymes
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Description

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Product Name:Human CINP Recombinant Protein
Product Code:RPPB2472
Size:20µg
Species:Human
Target:CINP
Synonyms:Cyclin-dependent kinase 2 interacting protein, CDK2-interacting protein, MGC849.
Source:Escherichia Coli
Physical Appearance:CINP is supplied as a sterile filtered clear solution.
Formulation:CINP protein (1mg/ml) is supplied in 20mM Tris-HCL, pH-8, 0.1M NaCl, 1mM DTT and 20% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MEAKTLGTVT PRKPVLSVSA RKIKDNAADW HNLILKWETL NDAGFTTANN IANLKISLLN KDKIELDSSS PASKENEEKV CLEYNEELEK LCEELQATLD GLTKIQVKME KLSSTTKGIC ELENYHYGEE SKRPPLFHTW PTTHFYEVSH KLLEMYRKEL LLKRTVAKEL AHTGDPDLTL SYLSMWLHQP YVESDSRLHL ESMLLETGHR AL

CINP is a member of the CINP family. CINP cooperates with the components of the replication complex and 2 kinases, CDK2 and CDC7, to provide a working and physical link between CDK2 and CDC7 throughout the firing of the origins of replication.

CINP Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 232 amino acids (1-212) and having a molecular mass of 26.4 kDa.The CINP is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:CINP: Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling. Belongs to the CINP family.Protein type: Motility/polarity/chemotaxis; Cell cycle regulationChromosomal Location of Human Ortholog: 14q32.31Cellular Component: nucleusMolecular Function: protein bindingBiological Process: cell division; DNA repair; cell cycle; DNA replication
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signaling as part of the DNA damage response. [provided by RefSeq, Jul 2013]
UniProt Code:Q9BW66
NCBI GenInfo Identifier:14249156
NCBI Gene ID:51550
NCBI Accession:NP_116019.1
UniProt Secondary Accession:Q9BW66,Q9NPF9, F5H7P3, F5H8A7
UniProt Related Accession:Q9BW66
Molecular Weight:26,051 Da
NCBI Full Name:cyclin-dependent kinase 2-interacting protein
NCBI Synonym Full Names:cyclin-dependent kinase 2 interacting protein
NCBI Official Symbol:CINP��
NCBI Official Synonym Symbols:
NCBI Protein Information:cyclin-dependent kinase 2-interacting protein; CDK2-interacting protein
UniProt Protein Name:Cyclin-dependent kinase 2-interacting protein
UniProt Synonym Protein Names:
Protein Family:Cyclin-dependent kinase 2-interacting protein
UniProt Gene Name:CINP��
UniProt Entry Name:CINP_HUMAN

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