Human CDO1 Recombinant Protein (RPPB5805)
- SKU:
- RPPB5805
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q16878
- Research Area:
- Enzymes
Description
| Product Name: | Human CDO1 Recombinant Protein |
| Product Code: | RPPB5805 |
| Size: | 50µg |
| Species: | Human |
| Target: | CDO1 |
| Synonyms: | Cysteine dioxygenase type 1, Cysteine dioxygenase type I, CDO-I, CDO, CDO1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CDO1 solution contains 20mM Tris buffer(pH 8.0), 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMEQ TEVLKPRTLA DLIRILHQLF AGDEVNVEEV QAIMEAYESD PTEWAMYAKF DQYRYTRNLV DQGNGKFNLM ILCWGEGHGS SIHDHTNSHC FLKMLQGNLK ETLFAWPDKK SNEMVKKSER VLRENQCAYI NDSVGLHRVE NISHTEPAVS LHLYSPPFDT CHAFDQR |
CDO1 (Cysteine dioxygenase) is a mammalian non-heme iron enzyme that initiates a number of significant metabolic pathways associated with pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. CDO1 catalyzes the conversion of L-cysteine to cysteine sulfinic acid (cysteine sulfinate) by incorporation of dioxygen. CDO1 is a vital regulator of cellular cysteine concentrations and has an essential role in maintaining the hepatic concentration of intracellular free cysteine within a proper narrow range. CDO1 is able to alter intracellular cysteine levels and glutathione levels. CDO1 is highly expressed in the liver and placenta. On the other hand CDO1 has a low expression in heart, brain and pancreas. CDO1 can also be detected in hepatoblastoma HepG2 cells.
CDO1 Human Recombinant fused with a 37 amino acids His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 207 amino acids (1-170 a.a.) and having a molecular mass of 23.9kDa.The CDO1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. |
| UniProt Code: | Q16878 |
| NCBI GenInfo Identifier: | 1021312321 |
| NCBI Gene ID: | 1036 |
| NCBI Accession: | NP_001310494.1 |
| UniProt Secondary Accession: | Q16878,P78513, Q6FHZ8, Q8TB64, B2RAK4, |
| UniProt Related Accession: | Q16878 |
| Molecular Weight: | 23 kDa |
| NCBI Full Name: | cysteine dioxygenase type 1 isoform 1 |
| NCBI Synonym Full Names: | cysteine dioxygenase type 1 |
| NCBI Official Symbol: | CDO1�� |
| NCBI Official Synonym Symbols: | CDO-I�� |
| NCBI Protein Information: | cysteine dioxygenase type 1 |
| UniProt Protein Name: | Cysteine dioxygenase type 1 |
| UniProt Synonym Protein Names: | Cysteine dioxygenase type I; CDO; CDO-I |
| Protein Family: | Cysteine dioxygenase |
| UniProt Gene Name: | CDO1�� |
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