Human CDKN3 Recombinant Protein (RPPB2469)
- SKU:
- RPPB2469
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q16667
- Research Area:
- Enzymes
Description
| Product Name: | Human CDKN3 Recombinant Protein |
| Product Code: | RPPB2469 |
| Size: | 20µg |
| Species: | Human |
| Target: | CDKN3 |
| Synonyms: | Cyclin-dependent kinase inhibitor 3, CDK2-associated dual-specificity phosphatase, Cyclin-dependent kinase interactor 1, Cyclin-dependent kinase-interacting protein 2, Kinase-associated phosphatase, KAP, CDI1, CIP2, KAP1, FLJ25787, MGC70625, CDKN3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CDKN3 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 40% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MKPPSSIQTS EFDSSDEEPI EDEQTPIHIS WLSLSRVNCS QFLGLCALPG CKFKDVRRNV QKDTEELKSC GIQDIFVFCT RGELSKYRVP NLLDLYQQCG IITHHHPIAD GGTPDIASCC EIMEELTTCL KNYRKTLIHC YGGLGRSCLV AACLLLYLSD TISPEQAIDS LRDLRGSGAI QTIKQYNYLH EFRDKLAAHL SSRDSQSRSV SR |
Cyclin-dependent kinase inhibitor 3 (CDKN3) is a member of the dual specificity protein phosphatase family. CDKN3 was identified as a cyclin-dependent kinase inhibitor, and was shown to interact with, and dephosphorylate CDK2 kinase, consequently prevent the activation of CDK2 kinase. In addition CDKN3 is important in cell cycle regulation. The CDKN3 gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.
CDKN3 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 232 amino acids (1-212 a.a.) and having a molecular mass of 25.9kDa. The CDKN3 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CDKN3: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner. Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC). Belongs to the protein-tyrosine phosphatase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 3.1.3.16; Cell cycle regulation; EC 3.1.3.48 Chromosomal Location of Human Ortholog: 14q22 Cellular Component: perinuclear region of cytoplasm; cytoplasm Molecular Function:protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein serine/threonine phosphatase activity Biological Process: negative regulation of cell proliferation; regulation of cyclin-dependent protein kinase activity; cell cycle arrest; G1/S transition of mitotic cell cycle Disease: Hepatocellular Carcinoma |
| NCBI Summary: | The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| UniProt Code: | Q16667 |
| NCBI GenInfo Identifier: | 2499769 |
| NCBI Gene ID: | 1033 |
| NCBI Accession: | Q16667.1 |
| UniProt Related Accession: | Q16667 |
| Molecular Weight: | 23805 Da |
| NCBI Full Name: | Cyclin-dependent kinase inhibitor 3 |
| NCBI Synonym Full Names: | cyclin dependent kinase inhibitor 3 |
| NCBI Official Symbol: | CDKN3�� |
| NCBI Official Synonym Symbols: | KAP; CDI1; CIP2; KAP1�� |
| NCBI Protein Information: | cyclin-dependent kinase inhibitor 3 |
| UniProt Protein Name: | Cyclin-dependent kinase inhibitor 3 |
| UniProt Synonym Protein Names: | CDK2-associated dual-specificity phosphatase; Cyclin-dependent kinase interactor 1; Cyclin-dependent kinase-interacting protein 2; Kinase-associated phosphatase |
| Protein Family: | Cyclin-dependent kinase inhibitor |
| UniProt Gene Name: | CDKN3�� |
| UniProt Entry Name: | CDKN3_HUMAN |
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