Human CD99 Recombinant Protein (RPPB3105)
- SKU:
- RPPB3105
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P14209
- Research Area:
- CD Antigens
Description
| Product Name: | Human CD99 Recombinant Protein |
| Product Code: | RPPB3105 |
| Size: | 10µg |
| Species: | Human |
| Target: | CD99 |
| Synonyms: | CD99 antigen, T-cell surface glycoprotein E2, E2 antigen, Protein MIC2, 12E7, CD99, MIC2, MIC2X, MIC2Y. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | CD99 protein solution (1mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPDGGFDLS DALPDNENKK PTAIPKKPSA GDDFDLGDAV VDGENDDPRP PNPPKPMPNP NPNHPSSSGS FSDADLADGV SGGEGKGGSD GGGSHRKEGE EADLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH |
CD99, or MIC2 gene product, or E2 antigen is expressed on the cell membrane of some lymphocytes, cortical thymocytes, and granulosa cells of the ovary. The antigen is also expressed by most pancreatic islet cells, Sertoli cells of the testis, and some endothelial cells. Mature granulocytes express very little or no CD99. MIC2 is strongly expressed on Ewing�s sarcoma cells and primitive peripheral neuroectodermal tumors.
CD99 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 342 amino acids (23-122a.a.) and having a molecular mass of 37.3kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).CD99 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes. |
| NCBI Summary: | The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus. [provided by RefSeq, Mar 2016] |
| UniProt Code: | P14209 |
| NCBI GenInfo Identifier: | 119049 |
| NCBI Gene ID: | 4267 |
| NCBI Accession: | P14209.1 |
| UniProt Secondary Accession: | P14209,O00518, Q6ICV7, A6NIW1, |
| UniProt Related Accession: | P14209 |
| Molecular Weight: | 17,128 Da |
| NCBI Full Name: | CD99 antigen |
| NCBI Synonym Full Names: | CD99 molecule (Xg blood group) |
| NCBI Official Symbol: | CD99�� |
| NCBI Official Synonym Symbols: | MIC2; HBA71; MIC2X; MIC2Y; MSK5X�� |
| NCBI Protein Information: | CD99 antigen |
| UniProt Protein Name: | CD99 antigen |
| UniProt Synonym Protein Names: | 12E7; E2 antigen; Protein MIC2; T-cell surface glycoprotein E2; CD_antigen: CD99 |
| Protein Family: | CD99 antigen |
| UniProt Gene Name: | CD99�� |
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