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Human CD9 Recombinant Protein (RPPB3031)

SKU:
RPPB3031
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P21926
Research Area:
CD Antigens
€309
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Description

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Product Name:Human CD9 Recombinant Protein
Product Code:RPPB3031
Size:20µg
Species:Human
Target:CD9
Synonyms:CD9 antigen, 5H9 antigen, Cell growth-inhibiting gene 2 protein, Leukocyte antigen MIC3, Motility-related protein, CD9, MRP-1, Tetraspanin-29, Tspan-29, p24, MIC3, TSPAN29, GIG2, BTCC-1, DRAP-27, TSPAN-29.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The CD9 solution (0.25mg/1ml) contains Phosphate buffer saline (pH 7.4), 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSSHKDEVI KEVQEFYKDT YNKLKTKDEP QRETLKAIHY ALNCCGLAGG VEQFISDICP KKDVLETFTV KSCPDAIKEV FDNKFHI

CD9 which is found on the surface of exosomes is a cell surface glycoprotein which is interacts with integrins and various transmembrane superfamily proteins. CD9 is involved in platelet activation and aggregation and also regulates paranodal junction formation. CD9 takes part in cell adhesion and migration and also promotes muscle cell fusion. CD9 is necessary for the egg-sperm fusion during mammalian fertilization.

CD9 Human Recombinant produced in E. coli is a single polypeptide chain containing 107 amino acids (112-195) and having a molecular mass of 12kDa.CD9 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CD9: Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion. Belongs to the tetraspanin (TM4SF) family.
UniProt Protein Details:

Protein type:Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: extracellular space; focal adhesion; integral to plasma membrane; membrane; plasma membrane; platelet alpha granule membrane

Molecular Function:protein binding

Biological Process: cell adhesion; cell motility; cell surface receptor linked signal transduction; fusion of sperm to egg plasma membrane; paranodal junction assembly; platelet degranulation; receptor internalization

NCBI Summary:This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins. The encoded protein functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis. [provided by RefSeq, Jan 2011]
UniProt Code:P21926
NCBI GenInfo Identifier:231724
NCBI Gene ID:928
NCBI Accession:P21926.4
UniProt Secondary Accession:P21926,Q5J7W6, Q96ES4, D3DUQ9,
UniProt Related Accession:P21926
Molecular Weight:
NCBI Full Name:CD9 antigen
NCBI Synonym Full Names:CD9 molecule
NCBI Official Symbol:CD9��
NCBI Official Synonym Symbols:MIC3; MRP-1; BTCC-1; DRAP-27; TSPAN29; TSPAN-29��
NCBI Protein Information:CD9 antigen
UniProt Protein Name:CD9 antigen
UniProt Synonym Protein Names:5H9 antigen; Cell growth-inhibiting gene 2 protein; Leukocyte antigen MIC3; Motility-related protein; MRP-1; Tetraspanin-29; Tspan-29; p24; CD_antigen: CD9
Protein Family:CD9 antigen
UniProt Gene Name:CD9��

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