The Human CD9 Monoclonal Antibody (HI9A, AGEL0322) is a vital tool for researchers studying CD9, a cell surface protein involved in various cellular processes. This monoclonal antibody, specifically designed for use with human samples, is raised in mice and has been validated for use in a range of applications, including immunohistochemistry and flow cytometry. By targeting the CD9 protein, researchers can detect and analyze its expression in different cell types, making it an essential tool for studies in cell biology, cancer research, and reproductive medicine.
CD9, also known as a member of the tetraspanin family, plays a crucial role in cell adhesion, migration, and signal transduction. Its involvement in these processes makes it a key player in various physiological and pathological conditions, including tumor metastasis, fertilization, and immune responses. By understanding the function of CD9, researchers can uncover new insights into these biological processes and potentially develop novel therapeutic strategies for conditions like cancer and infertility.
Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD9 is a 24 kD type III transmembrane protein also known as tetraspanin, MRP-1 and DRAP-24. It is a member of the tetraspan family (spanning the membrane four times) found on platelets, B cell progenitors, activated lymphocytes, granulocytes, endothelial cells and epithelial cells. CD9 induces adhesion, platelet aggregation, and B cell development. CD9 has been shown to associate with CD63, CD81, CD82, and CD36 and to bind to β1 integrins.