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PE/Cyanine5.5 Anti-Human CD8a Antibody [OKT-8] (AGEL1392)

SKU:
AGEL1392
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
$167 - $563
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Description

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PE/Cyanine5.5 Anti-Human CD8a Antibody [OKT-8]

The Human CD8a Monoclonal Antibody (PE/Cyanine5.5 Conjugated) - OKT-8 (AGEL1392) offered by AssayGenie is a powerful tool for researchers studying CD8a, a critical marker for cytotoxic T cells in the immune system. This antibody, conjugated with PE/Cyanine5.5 for flow cytometry applications, is specifically designed for high reactivity with human samples.CD8a is a key protein found on cytotoxic T cells, playing a crucial role in the body's immune response against pathogens and abnormal cells. By targeting CD8a, researchers can analyze and characterize T cell populations in various tissues, aiding in the understanding of immune responses in health and disease.

The OKT-8 antibody provides researchers with a reliable tool for studying CD8a expression in different cell types and experimental conditions. Its fluorescence conjugation allows for precise detection and analysis of CD8a-positive cells, making it valuable for immunology research, cancer immunotherapy studies, and investigations into autoimmune diseases.By utilizing the Human CD8a Monoclonal Antibody (PE/Cyanine5.5 Conjugated) - OKT-8 (AGEL1392), researchers can further explore the role of CD8a in immune function, disease pathogenesis, and potential therapeutic strategies targeting cytotoxic T cells.

Product Title:PE/Cyanine5.5 Anti-Human CD8a Antibody [OKT-8]
SKU:AGEL1392
Size:20 Tests, 100 Tests, 200 Tests
Clone No:OKT-8
Synonyms:T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:PE/Cyanine5.5 Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:PE/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P01732
Gene ID:925
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.

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