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APC Anti-Human CD8a Antibody [OKT-8] (AGEL0409)

SKU:
AGEL0409
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
OKT-8
Conjugation:
APC
Applications:
FC
€109 - €289
Frequently bought together:

Description

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APC Anti-Human CD8a Antibody [OKT-8]

The Human CD8a Monoclonal Antibody (APC Conjugated) - OKT-8 (AGEL0409) is a cutting-edge tool for researchers investigating the CD8a cell surface antigen, a key marker of cytotoxic T cells involved in immune response. This monoclonal antibody, conjugated with APC for fluorescence detection, specifically targets and binds to the CD8a protein, enabling precise identification and analysis of CD8a-expressing cells in human samples.CD8a is a crucial component of adaptive immunity, playing a critical role in recognizing and eliminating infected or abnormal cells. By targeting CD8a, researchers can gain valuable insights into the function and behavior of cytotoxic T cells in various biological processes, including immune responses to pathogens, tumor surveillance, and autoimmune disorders.

With its high specificity and sensitivity, the Human CD8a Monoclonal Antibody (APC Conjugated) - OKT-8 (AGEL0409) is an indispensable tool for studies in immunology, oncology, and infectious diseases. Its ability to detect and quantitate CD8a expression in diverse experimental settings makes it an essential reagent for researchers seeking to unravel the complexities of immune-mediated processes and develop novel therapeutic strategies.

Product Title:APC Anti-Human CD8a Antibody [OKT-8]
SKU:AGEL0409
Size:20 Tests, 100 Tests, 200 Tests
Clone No:OKT-8
Synonyms:T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:APC Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P01732
Gene ID:925
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.

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