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Purified Anti-Human CD8a Antibody [OKT-8] (AGEL0405)

SKU:
AGEL0405
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
OKT-8
Conjugation:
Unconjugated
Applications:
FC
$107 - $227
Frequently bought together:

Description

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Purified Anti-Human CD8a Antibody [OKT-8]

The CD8 Monoclonal Antibody (OKT-8, AGEL0405) is a cutting-edge tool for researchers delving into the realm of immune cell biology. This monoclonal antibody, specifically targeting the CD8 protein found on cytotoxic T cells, offers a powerful means of studying immune responses and cell-mediated immunity in humans. Derived from mouse hybridoma technology, this antibody exhibits high reactivity and specificity towards human CD8, making it a dependable choice for various immunological assays, including flow cytometry and immunohistochemistry. By binding to the CD8 protein, this antibody enables precise detection and characterization of CD8+ T cells in diverse experimental settings.CD8 is a pivotal marker for identifying cytotoxic T lymphocytes, a crucial component of the adaptive immune system responsible for recognizing and eliminating infected or cancerous cells.

Research involving CD8 holds immense potential in shedding light on immune responses to pathogens, vaccines, and tumors, making this monoclonal antibody a valuable asset for investigations in immunology, infectious diseases, and cancer immunotherapy.By leveraging the specificity and sensitivity of the CD8 Monoclonal Antibody (OKT-8, AGEL0405), researchers can unravel the intricate mechanisms underlying immune cell function and design innovative strategies for enhancing immune-mediated therapies and disease treatments.

Product Title:Purified Anti-Human CD8a Antibody [OKT-8]
SKU:AGEL0405
Size:25µg, 100µg
Clone No:OKT-8
Synonyms:T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:Purified Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P01732
Gene ID:925
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.

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