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PE/Cyanine5.5 Anti-Human CD74 Antibody [LN2] (AGEL1056)

SKU:
AGEL1056
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
€259 - €889
Frequently bought together:

Description

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PE/Cyanine5.5 Anti-Human CD74 Antibody [LN2]

The Human CD74 Monoclonal Antibody (PE/Cyanine5.5 Conjugated) LN2 (AGEL1056) is a powerful tool for researchers investigating CD74, a key protein involved in immune regulation and antigen presentation. This monoclonal antibody, conjugated with PE/Cyanine5.5, offers high specificity and sensitivity in detecting CD74 in human samples. CD74, also known as the major histocompatibility complex (MHC) class II invariant chain, plays a pivotal role in the adaptive immune response by facilitating antigen presentation to T cells. Its expression is crucial for immune surveillance and activation of the immune system against pathogens and abnormal cells. The CD74 Monoclonal Antibody allows for precise visualization and quantification of CD74 levels in various cell types, making it an essential tool for immunology and cancer research.

Given the role of CD74 in immune function and its potential implications in diseases such as cancer, autoimmune disorders, and inflammatory conditions, studying its expression and regulation is vital for understanding disease mechanisms and developing targeted therapies. The CD74 Monoclonal Antibody (PE/Cyanine5.5 Conjugated) LN2 (AGEL1056) provides researchers with a reliable means to explore the involvement of CD74 in immune responses, making it a valuable asset in advancing scientific knowledge and improving healthcare outcomes.

Product Title:PE/Cyanine5.5 Anti-Human CD74 Antibody [LN2]
SKU:AGEL1056
Size:20 Tests, 100 Tests, 200 Tests
Clone No:LN2
Synonyms:HLA class II histocompatibility antigen gamma chain;CD74;Ia antigen-associated invariant chain;Ii;p33;DHLAG;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE/Cyanine5.5 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P04233
Gene ID:972
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-κB activation, and IL-8 production.

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