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PE Anti-Human CD74 Antibody [LN2] (AGEL1052)

SKU:
AGEL1052
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a,k
Clone:
LN2
Conjugation:
PE
$227 - $755
Frequently bought together:

Description

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PE Anti-Human CD74 Antibody [LN2]

The Human CD74 Monoclonal Antibody PE Conjugated (LN2) is a vital tool for researchers studying immune responses and antigen presentation. This monoclonal antibody, labeled with PE for flow cytometry applications, specifically targets CD74, a cell surface protein involved in antigen processing and presentation. By binding to CD74, this antibody enables the precise detection and analysis of CD74 expression on various immune cell types, facilitating investigations into immune system function and response.CD74, also known as the HLA-DR antigens associated invariant chain, plays a crucial role in the immune system by aiding in the loading of antigenic peptides for presentation to T cells. Its involvement in antigen presentation pathways makes it a key player in immune surveillance and response. Research on CD74 is essential for understanding how the immune system recognizes and responds to pathogens, tumors, and other foreign or abnormal cells.

Furthermore, the PE conjugation of this monoclonal antibody allows for the visualization and quantification of CD74 expression levels on individual cells, providing valuable insights into immune cell activation and differentiation. This antibody is validated for use in flow cytometry, making it a reliable tool for studying CD74 dynamics in various experimental settings.Overall, the Human CD74 Monoclonal Antibody PE Conjugated (LN2) is a valuable resource for researchers interested in unraveling the intricate mechanisms of antigen presentation and immune responses. Its specificity, reliability, and compatibility with flow cytometry make it an indispensable asset in immunology and cancer research, offering new opportunities for advancing our understanding of immune system function and its implications in health and disease.

Product Title:PE Anti-Human CD74 Antibody [LN2]
SKU:AGEL1052
Size:20 Tests, 100 Tests, 200 Tests
Clone No:LN2
Synonyms:HLA class II histocompatibility antigen gamma chain;CD74;Ia antigen-associated invariant chain;Ii;p33;DHLAG;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P04233
Gene ID:972
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-κB activation, and IL-8 production.

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