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GenieFluor 647 Anti-Human CD74 Antibody [LN2] (AGEL1059)

SKU:
AGEL1059
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
$311 - $1,067
Frequently bought together:

Description

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GenieFluor 647 Anti-Human CD74 Antibody [LN2]

The Human CD74 Monoclonal Antibody (AF647 Conjugated) LN2 (AGEL1059) is a vital tool for researchers studying CD74, a cell surface glycoprotein involved in antigen presentation and immune response regulation. This monoclonal antibody, conjugated with AF647 for detection purposes, is specifically designed for use in fluorescence-based assays and imaging techniques.CD74, also known as the MHC class II-associated invariant chain, plays a crucial role in the processing and presentation of antigens to immune cells, thereby influencing immune system activation and regulation. By targeting CD74 with this highly specific monoclonal antibody, researchers can gain insights into the expression and localization of CD74 in various cell types and tissues.

The use of AF647 conjugation enables precise visualization of CD74 in fluorescence microscopy and flow cytometry experiments, enhancing the accuracy and sensitivity of detection. With its proven specificity and reliability, the Human CD74 Monoclonal Antibody (AF647 Conjugated) LN2 (AGEL1059) is an invaluable asset for studies related to antigen presentation, immune response modulation, and immunotherapy research.

Product Title:GenieFluor 647 Anti-Human CD74 Antibody [LN2]
SKU:AGEL1059
Size:20 Tests, 100 Tests, 200 Tests
Clone No:LN2
Synonyms:HLA class II histocompatibility antigen gamma chain;CD74;Ia antigen-associated invariant chain;Ii;p33;DHLAG;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Genie Fluor 647 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P04233
Gene ID:972
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-κB activation, and IL-8 production.

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