Human CD72 Recombinant Protein (RPPB3090)
- SKU:
- RPPB3090
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P21854
- Research Area:
- CD Antigens
Description
| Product Name: | Human CD72 Recombinant Protein |
| Product Code: | RPPB3090 |
| Size: | 10µg |
| Species: | Human |
| Target: | CD72 |
| Synonyms: | CD72, CD72b, LYB2, B-cell differentiation antigen CD72, Lyb-2. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CD72 protein solution (0.5mg/ml) contains 50mM Tris-HCl buffer (pH6.8), 0.2M NaCl, 2mM DTT and 50% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPRYLQVSQ QLQQTNRVLE VTNSSLRQQL RLKITQLGQS AEDLQGSRRE LAQSQEALQVEQRAHQAAEG QLQACQADRQ KTKETLQSEE QQRRALEQKL SNMENRLKPF FTCGSADTCCPSGWIMHQKS CFYISLTSKN WQESQKQCET LSSKLATFSE IYPQSHSYYF LNSLLPNGGSGNSYWTGLSS NKDWKLTDDT QRTRTYAQSS KCNKVHKTWS WWTLESESCR SSLPYICEMTAFRFPDLEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSHEDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKALPAPIEKTISK AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPENNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGKH HHHHH |
CD72 antigen is a member of the type II integral membrane glycoproteins which includes other related cell surface moleculaes such as the asialoglycoprotein receptors, CD23 and the Kupffer cell recpeotr. The exposure of B cells to CD72 antibodies activates a variety of signalling pathways and can induce MHC class II expression and B cell proliferation. CD72 antigen is expressed on all cells of B cell lineage with the exception of plasma cells and weakly on human tissue macrophages.
CD72 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 485 amino acids (117-359a.a.) and having a molecular mass of 55.3kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa).CD72 is expressed with a 242 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CD72: Plays a role in B-cell proliferation and differentiation. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 9p13.3 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:protein binding; receptor binding Biological Process: cell adhesion |
| UniProt Code: | P21854 |
| NCBI GenInfo Identifier: | 116029 |
| NCBI Gene ID: | 971 |
| NCBI Accession: | P21854.1 |
| UniProt Related Accession: | P21854 |
| Molecular Weight: | 40,220 Da |
| NCBI Full Name: | B-cell differentiation antigen CD72 |
| NCBI Synonym Full Names: | CD72 molecule |
| NCBI Official Symbol: | CD72�� |
| NCBI Official Synonym Symbols: | LYB2; CD72b�� |
| NCBI Protein Information: | B-cell differentiation antigen CD72 |
| UniProt Protein Name: | B-cell differentiation antigen CD72 |
| UniProt Synonym Protein Names: | Lyb-2; CD_antigen: CD72 |
| Protein Family: | B-cell differentiation antigen |
| UniProt Gene Name: | CD72�� |
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