The Human CD58 Monoclonal Antibody (PE/Cyanine5 Conjugated, TS2/9.1) is a cutting-edge tool for researchers investigating CD58, a crucial cell-adhesion molecule involved in immune responses. This antibody, part of Assay Genie's advanced product line, is specifically designed for use in flow cytometry applications, enabling precise identification and analysis of CD58 expression in human samples.CD58, also known as LFA-3, plays a vital role in mediating interactions between immune cells, facilitating communication and coordination of immune responses. Its involvement in T-cell activation and antigen presentation makes it a key player in immune surveillance and regulation. Research focused on CD58 can provide insights into immune system function, autoimmune diseases, and transplantation biology.
The PE/Cyanine5 conjugation of this monoclonal antibody allows for multiparametric flow cytometry experiments, enhancing the specificity and sensitivity of CD58 detection. With its validated performance in detecting human CD58, this antibody is an essential tool for immunologists, oncologists, and researchers studying immune-related disorders.Unlock the potential of CD58 research with the Human CD58 Monoclonal Antibody (PE/Cyanine5 Conjugated, TS2/9.1) from Assay Genie. Explore the intricacies of immune cell interactions and advance your understanding of immune regulation with this innovative antibody.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P19256
Gene ID:
965
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD58, also known as lymphocyte function-associated antigen 3 (LFA-3) is a 45-70 kD cell surface protein that is a member of the immunoglobulin superfamily. Alternative splicing of CD58 gives rise to transmembrane and glycosylphosphatidylinositol (GPI)-anchored forms on cell surface. CD58 is expressed on both hematopoietic and non-hematopoietic cells including B cells, T cells, monocytes, erythrocytes, endothelial cells, epithelial cells, and fibroblasts. High levels are observed on memory T cells and dendritic cells. CD58 expressed on antigen presenting cells and target cells enhances T cell recognition via the binding of it's cognate ligand, CD2, on the T cell surface.