Human CD5 Recombinant Protein (RPPB3021)
- SKU:
- RPPB3021
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P06127
- Research Area:
- CD Antigens
Description
| Product Name: | Human CD5 Recombinant Protein |
| Product Code: | RPPB3021 |
| Size: | 10µg |
| Species: | Human |
| Target: | CD5 |
| Synonyms: | CD5 Molecule, Lymphocyte Antigen T1/Leu-1, CD5 Antigen (P56-62), LEU1, T-Cell Surface Glycoprotein CD5, CD5 Antigen, T1. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | CD5 protein solution (0.5mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPEFRLSWY DPDFQARLTR SNSKCQGQLE VYLKDGWHMV CSQSWGRSSK QWEDPSQASK VCQRLNCGVP LSLGPFLVTY TPQSSIICYG QLGSFSNCSH SRNDMCHSLG LTCLEPQKTT PPTTRPPPTT TPEPTAPPRL QLVAQSGGQH CAGVVEFYSG SLGGTISYEA QDKTQDLENF�LCNNLQCGSF LKHLPETEAG RAQDPGEPRE HQPLPIQWKI QNSSCTSLEH CFRKIKPQKS GRVLALLCSG FQPKVQSRLV GGSSICEGTV EVRQGAQWAA LCDSSSARSS LRWEEVCREQ QCGSVNSYRV LDAGDPTSRG LFCPHQKLSQ CHELWERNSY CKKVFVTCQD PNPHHHHHH |
CD5 is a suitable immunohistochemical marker for T-cells, though not as sensitive as CD3. Approximately 76% of T-cell neoplasms are reported to express CD5, and it is also observed in chronic lymphocytic leukemia, hairy cell leukemia, and mantle cell lymphoma cells. CD5 is commonly lost in cutaneous T-cell lymphoma, and its deficiency can be used as an indicator of malignancy in this condition. CD5�s absence in T cell acute lymphoblastic leukemia, though relatively rare, is linked with a poor prognosis. CD5 serves as a receptor in regulating T-cell proliferation.
CD5 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 359 amino acids (25-372a.a.) and having a molecular mass of 40kDa (Molecular size on SDS-PAGE will appear at approximately 40-57 kDa). CD5 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CD5: a surface glycoprotein expressed on T cells and B-1 B cells. Rapidly recruited to the immunological synapse, lowering the response of the T cell antigen receptor. CD5 interacts with CD72/LYB-2. Promotes B-cell survival through stimulation of autocrine IL-10 production. Contains 3 SRCR domains. |
| UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q13 Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane Molecular Function:protein binding; transmembrane receptor activity; receptor activity; scavenger receptor activity Biological Process: cell proliferation; receptor-mediated endocytosis; T cell costimulation; cell recognition |
| UniProt Code: | P06127 |
| NCBI GenInfo Identifier: | 313104090 |
| NCBI Gene ID: | 921 |
| NCBI Accession: | P06127.2 |
| UniProt Secondary Accession: | P06127,A0N0P4, A8K9I3, |
| UniProt Related Accession: | P06127 |
| Molecular Weight: | 459 |
| NCBI Full Name: | T-cell surface glycoprotein CD5 |
| NCBI Synonym Full Names: | CD5 molecule |
| NCBI Official Symbol: | CD5�� |
| NCBI Official Synonym Symbols: | T1; LEU1�� |
| NCBI Protein Information: | T-cell surface glycoprotein CD5; CD5 antigen (p56-62); lymphocyte antigen T1/Leu-1 |
| UniProt Protein Name: | T-cell surface glycoprotein CD5 |
| UniProt Synonym Protein Names: | Lymphocyte antigen T1/Leu-1; CD_antigen: CD5 |
| Protein Family: | CD5 antigen |
| UniProt Gene Name: | CD5�� |
| UniProt Entry Name: | CD5_HUMAN |
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