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GenieFluor 647 Anti-Human CD49d Antibody [BU49] (AGEL0888)

SKU:
AGEL0888
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a,k
Clone:
BU49
Conjugation:
AF 647
€239 - €769
Frequently bought together:

Description

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GenieFluor 647 Anti-Human CD49d Antibody [BU49]

The Human CD49d Monoclonal Antibody (AF647 Conjugated) from AssayGenie (Product Code: BU49-AGEL0888) is a cutting-edge tool for researchers investigating cell adhesion and migration processes in human samples. This high-quality antibody, conjugated with AF647 for fluorescent detection, is specifically designed to target CD49d, a key integrin subunit involved in cell-to-cell and cell-to-extracellular matrix interactions.With its superior reactivity and specificity for human CD49d, this monoclonal antibody is ideal for a wide range of applications, including flow cytometry, immunofluorescence, and immunohistochemistry. It allows for precise visualization and quantification of CD49d expression in various cell types and tissues, making it a valuable asset for studies in immunology, oncology, and cell biology.

CD49d, also known as VLA-4 alpha subunit, plays a crucial role in cell adhesion and migration processes, influencing immune cell trafficking, tissue inflammation, and cancer metastasis. By targeting CD49d with this monoclonal antibody, researchers can gain important insights into the mechanisms underlying these processes and develop innovative strategies for therapeutic intervention.For researchers seeking a reliable and efficient tool to study CD49d-mediated cell interactions, the Human CD49d Monoclonal Antibody (AF647 Conjugated) from AssayGenie is a must-have reagent that promises accurate and reproducible results in their experiments.

Product Title:GenieFluor 647 Anti-Human CD49d Antibody [BU49]
SKU:AGEL0888
Size:20 Tests, 100 Tests, 200 Tests
Clone No:BU49
Synonyms:Integrin alpha-4;ITGA4;CD49 antigen-like family member D;Integrin alpha-IV;VLA-4 subunit alpha;CD49d;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Genie Fluor 647 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P13612
Gene ID:3676
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD49d is a 150 kD α integrin chain known as α4 integrin or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.

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