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GenieFluor 647 Anti-Human CD49d Antibody [9F10] (AGEL1745)

SKU:
AGEL1745
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a,k
Clone:
9F10
Conjugation:
AF 647
€249 - €769
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Description

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GenieFluor 647 Anti-Human CD49d Antibody [9F10]

The Human CD49d Monoclonal Antibody (AF647 conjugated, 9F10) is a cutting-edge tool designed for researchers interested in investigating CD49d, a key integrin involved in cell adhesion and migration processes. This monoclonal antibody, conjugated with AF647 for fluorescent detection, offers high specificity and sensitivity when used in various experimental techniques, such as flow cytometry or immunofluorescence.CD49d, also known as integrin alpha-4, plays a crucial role in mediating cell adhesion to vascular cell adhesion molecule-1 (VCAM-1), a process essential for immune cell trafficking and inflammatory responses. By targeting CD49d with this monoclonal antibody, researchers can explore its function in immune cell recruitment, tissue inflammation, and potential therapeutic interventions in diseases like multiple sclerosis, inflammatory bowel disease, and atherosclerosis.

This AF647-conjugated CD49d monoclonal antibody (9F10) from Assay Genie provides a reliable tool for studying the mechanisms of cell adhesion and migration mediated by integrin alpha-4, offering valuable insights into the pathophysiology of various inflammatory and autoimmune conditions. Unlock the potential of CD49d research with this advanced antibody for precise and accurate detection in your experimental investigations.

Product Title:GenieFluor 647 Anti-Human CD49d Antibody [9F10]
SKU:AGEL1745
Size:20 Tests, 100 Tests, 200 Tests
Clone No:9F10
Synonyms:Integrin alpha-4;CD49 antigen-like family member D;Integrin alpha-IV;VLA-4 subunit alpha;CD49d;ITGA4;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Genie Fluor 647 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P13612
Gene ID:3676
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD49d is a 150 kD α integrin chain known as α4 integrin or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.

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