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GenieFluor 488 Anti-Human CD49d Antibody [9F10] (AGEL1744)

SKU:
AGEL1744
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
€289 - €939

Description

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GenieFluor 488 Anti-Human CD49d Antibody [9F10]

The Human CD49d Monoclonal Antibody (AF488 Conjugated, 9F10) is a cutting-edge tool for researchers studying CD49d, a key cell adhesion molecule involved in cell migration and interaction within the immune system. This monoclonal antibody, conjugated with AF488 for fluorescence-based applications, offers high specificity and sensitivity in detecting CD49d expression in human samples.CD49d, also known as integrin alpha-4, plays a vital role in immune cell trafficking and homing to specific tissues during inflammatory responses and immune surveillance. The precise targeting of CD49d by this antibody enables researchers to investigate its involvement in various biological processes, including leukocyte recruitment, cell signaling, and immune cell activation.

By utilizing the Human CD49d Monoclonal Antibody (AF488 Conjugated, 9F10), researchers can gain deeper insights into the function and regulation of CD49d in immune-related processes, making it an invaluable tool for studies focused on immune cell adhesion, migration, and immune-mediated diseases. This antibody is optimized for various immunofluorescence and flow cytometry applications, allowing for comprehensive analysis of CD49d expression patterns in different cell types and experimental conditions.

Product Title:GenieFluor 488 Anti-Human CD49d Antibody [9F10]
SKU:AGEL1744
Size:20 Tests, 100 Tests, 200 Tests
Clone No:9F10
Synonyms:Integrin alpha-4;CD49 antigen-like family member D;Integrin alpha-IV;VLA-4 subunit alpha;CD49d;ITGA4;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Genie Fluor 488 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P13612
Gene ID:3676
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD49d is a 150 kD α integrin chain known as α4 integrin or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.

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