Human CD45RA Polyclonal Antibody (CAB24839)
- SKU:
- CAB24839
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IF
Description
Product Name: | Human CD45RA Polyclonal Antibody |
SKU: | CAB24839 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 10-110 of human CD45RA(P08575-8). |
Sequence: | LAFG FAFL DTEV FVTG QSPT PSPT GLTT AKMP SVPL SSDP LPTH TTAF SPAS TFER ENDF SETT TSLS PDNT STQV SPDS LDNA SAFN TTDA YLNA SETT T |
Tested Applications: | IF/ICC |
Recommended Dilution: | IF/ICC,1:50 - 1:200 |
Synonyms: | PTPRC; B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200; receptor-type tyrosine-protein phosphatase C; Human CD45RA |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Membrane raft, Single-pass type I membrane protein. |
Calculated MW: | 130kDa/147kDa |
Observed MW: | Refer to figures |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
Purification Method: | Affinity purification |
Gene ID: | 5788 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |