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Human CD45RA Polyclonal Antibody (CAB24839)

SKU:
CAB24839
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
IF
€129 - €359
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Description

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Human CD45RA Polyclonal Antibody (CAB24839)

The Human CD45RA Polyclonal Antibody is a powerful tool for researchers studying the CD45RA protein, a marker of naive T cells in the immune system. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in various applications including immunohistochemistry, flow cytometry, and ELISA.CD45RA is a key protein involved in the regulation of T cell activation and differentiation, making it a crucial target for studies in immunology, autoimmune diseases, and infectious diseases.

By detecting and analyzing CD45RA expression in different cell types, researchers can gain insight into the immune response and develop new therapies for a variety of conditions.With its high reactivity and specificity, the Human CD45RA Polyclonal Antibody is the ideal choice for researchers looking to explore the role of CD45RA in immune function and disease pathology.

Product Name:Human CD45RA Polyclonal Antibody
SKU:CAB24839
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 10-110 of human CD45RA(P08575-8).
Sequence:LAFG FAFL DTEV FVTG QSPT PSPT GLTT AKMP SVPL SSDP LPTH TTAF SPAS TFER ENDF SETT TSLS PDNT STQV SPDS LDNA SAFN TTDA YLNA SETT T
Tested Applications:IF/ICC
Recommended Dilution:IF/ICC,1:50 - 1:200
Synonyms:PTPRC; B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200; receptor-type tyrosine-protein phosphatase C; Human CD45RA
Conjugate:Unconjugated
Cellular Localization:Membrane, Membrane raft, Single-pass type I membrane protein.
Calculated MW:130kDa/147kDa
Observed MW:Refer to figures

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Purification Method:Affinity purification
Gene ID:5788
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageImmunofluorescence analysis of paraffin-embedded human tonsil using Human CD45RA Rabbit pAb (CAB24839) at dilution of 1:50 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IF staining protocol.

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