The Human CD45RA Monoclonal Antibody (PERCP-conjugated) is a vital tool for research in immunology and cell biology. This antibody, designated HI100 (AGEL0956), is specifically designed to target the CD45RA antigen, a marker of naive T cells in the human immune system.Utilizing the PERCP conjugation, this monoclonal antibody provides excellent sensitivity and specificity in flow cytometry applications, enabling precise detection and analysis of CD45RA expression in various cell populations. With its high reactivity towards human samples, this antibody is a reliable tool for studying immune cell subsets and their functions.The CD45RA antigen is crucial for understanding immune cell differentiation and activation states, making this antibody an essential component for research on immune responses, autoimmunity, and infectious diseases.
Its precise targeting of CD45RA allows for detailed investigations into T cell subpopulations and their roles in immune surveillance and response mechanisms.Researchers in immunology, virology, and autoimmune disease disciplines can benefit greatly from the versatility and efficiency of the Human CD45RA Monoclonal Antibody (PERCP-conjugated), enabling groundbreaking discoveries and advancements in the field of human immunology.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P08575
Gene ID:
5788
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD45RA is a 205-220 kD single chain type I glycoprotein. It is an exon 4 splice variant of the tyrosine phosphatase CD45. The CD45RA isoform is expressed on resting/naïve T cells, medullary thymocytes, B cells and monocytes. CD45RA enhances both T cell receptor and B cell receptor signaling. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1. CD45 isoform expression can change in response to cytokines.