The Human CD4 Monoclonal Antibody (PERCP-Cyanine5.5 Conjugated) RPA-T4 (AGEL1388) is a specialized antibody designed for research involving the CD4 protein, a crucial marker for T helper cells in the immune system. This monoclonal antibody, tagged with PERCP-Cyanine5.5 for fluorescence detection, specifically targets the CD4 antigen in human samples with high specificity and sensitivity.CD4 is a key protein involved in the immune response, playing a significant role in activating T cells and coordinating the body's defense against pathogens. The monoclonal antibody RPA-T4 (AGEL1388) enables precise detection and analysis of CD4-expressing cells in various research applications, such as flow cytometry and immunofluorescence studies.
Understanding the expression and function of CD4 is essential for studying immune responses, infectious diseases, autoimmune disorders, and immunodeficiencies. This monoclonal antibody provides researchers with a reliable tool to investigate the distribution, levels, and interactions of CD4-positive cells, contributing to advancements in immunology, vaccine development, and potential therapeutic strategies targeting CD4-related pathways.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P01730
Gene ID:
920
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD4, also known as T4/Leu-3, is a 55 kD single-chain type I transmembrane glycoprotein and member of the immunoglobulin superfamily. It is expressed on most thymocytes, helper T cells, type II NKT cells, and monocytes/macrophages. CD4 is part of the TCR/CD3 complex, binds to β2 domain from the MHC class II molecule, and participates in TCR signal transduction. CD4 is the receptor of IL-16 and is a coreceptor for the human immunodeficiency virus (HIV) and human herpes virus 7 (HHV-7).