The Human CD3e Polyclonal Antibody is a valuable tool for researchers studying CD3e, a key protein found on T cells that plays a critical role in immune response and regulation. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.CD3e is a crucial component of the T cell receptor complex, involved in signaling pathways that activate T cells and contribute to immune responses. By targeting CD3e, researchers can better understand T cell function and activation processes in various immunological contexts, from infectious diseases to cancer.
The Human CD3e Polyclonal Antibody is an essential tool for immunology research, providing reliable detection and analysis of CD3e protein expression in different cell types. Its versatility and specificity make it ideal for studying T cell biology, immune system function, and potential therapeutic targets for immune-related diseases.
Product Name:
Human CD3E Polyclonal Antibody
SKU:
CAB24879
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-126 of human CD3E(NP_000724.1).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
23kDa
Observed MW:
23kDa/
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
Purification Method:
Affinity purification
Gene ID:
916
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Human CD3E Rabbit pAb (CAB24879) at 1:900 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Negative control (NC): PC-3.Exposuretime: 1s.
