Human CD38 Recombinant Protein (RPPB5871)
- SKU:
- RPPB5871
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P28907
- Research Area:
- CD Antigens
Description
| Product Name: | Human CD38 Recombinant Protein |
| Product Code: | RPPB5871 |
| Size: | 10µg |
| Species: | Human |
| Target: | CD38 |
| Synonyms: | P28907, ADP-Ribosyl Cyclase 1,2-Phospho-Cyclic-ADP-Ribose Transferase, Cyclic ADP-Ribose Hydrolase,2-Phospho-ADP-Ribosyl Cyclase, NAD(+) Nucleosidase, CD38 Antigen (P45), ADPRC1, 2-Phospho-ADP-Ribosyl Cyclase/2-Phospho-Cyclic-ADP-Ribose Transferase,Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase , Cluster OfDifferentiation 38, CADPr Hydrolase 1,CD38 Antigen, EC 2.4.99.20, EC 3.2.2.6,ADPRC1, T10. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CD38protein solution (1mg/ml) contains 100mM NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPEFVPRWRQQWSGPGTTK RFPETVLARC VKYTEIHPEM RHVDCQSVWD AFKGAFISKH PCNITEEDYQ PLMKLGTQTVPCNKILLWSR IKDLAHQFTQ VQRDMFTLED TLLGYLADDL TWCGEFNTSK INYQSCPDWR KDCSNNPVSVFWKTVSRRFA EAACDVVHVM LNGSRSKIFD KNSTFGSVEV HNLQPEKVQT LEAWVIHGGR EDSRDLCQDPTIKELESIIS KRNIQFSCKN IYRPDKFLQC VKNPEDSSCT SEIHHHHHH |
CD38 is a surface molecule which acts as a plasma membrane signaling receptorin leukocytes. Furthermore, CD38 functionsas signaling channel which leads to to cellular activation and proliferation. CD38 also plays a role as an ectoenzyme with variousfunctions as well as an inducer of Ca2+ mobilization from cytoplasmic stores. CD38 signals acts as a coreceptor on B cells andmodulates B cell receptor.
CD38 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 269 amino acids (43-300 a.a.) andhaving a molecular mass of 31.2kDa (Migrates at 28-40kDa on SDS-PAGE underreducing conditions).CD38 is expressed with a 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.2.2.6; EC 2.4.99.20; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Hydrolase; Cell surface; Apoptosis; Lyase; Membrane protein, integral; Cell cycle regulation Chromosomal Location of Human Ortholog: 4p15 Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; nucleus Molecular Function:transferase activity; phosphorus-oxygen lyase activity; NAD+ nucleosidase activity; NAD(P)+ nucleosidase activity Biological Process: response to drug; response to retinoic acid; metabolic process; positive regulation of transcription, DNA-dependent; positive regulation of insulin secretion; female pregnancy; signal transduction; positive regulation of cell growth; response to estradiol stimulus; B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; response to hydroperoxide; positive regulation of B cell proliferation; positive regulation of vasoconstriction; response to hypoxia; response to progesterone stimulus; negative regulation of transcription, DNA-dependent; negative regulation of bone resorption; negative regulation of apoptosis |
| NCBI Summary: | CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P28907 |
| NCBI GenInfo Identifier: | 55977782 |
| NCBI Gene ID: | 952 |
| NCBI Accession: | P28907.2 |
| UniProt Secondary Accession: | P28907,O00121, O00122, Q96HY4, |
| UniProt Related Accession: | P28907 |
| Molecular Weight: | 300 |
| NCBI Full Name: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
| NCBI Synonym Full Names: | CD38 molecule |
| NCBI Official Symbol: | CD38�� |
| NCBI Official Synonym Symbols: | T10; ADPRC 1�� |
| NCBI Protein Information: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; CD38 antigen (p45); NAD(+) nucleosidase; ADP-ribosyl cyclase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase |
| UniProt Protein Name: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
| UniProt Synonym Protein Names: | 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20); 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD_antigen: CD38 |
| Protein Family: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase |
| UniProt Gene Name: | CD38�� |
| UniProt Entry Name: | CD38_HUMAN |
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