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PE Anti-Human CD28 Antibody [CD28.2] (AGEL2021)

SKU:
AGEL2021
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
€129 - €449
Frequently bought together:

Description

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PE Anti-Human CD28 Antibody [CD28.2]

The Human CD28 Monoclonal Antibody PE Conjugated (CD28-2) is a specialized tool designed for researchers studying CD28, a crucial co-stimulatory molecule essential for T cell activation and immune response regulation. This antibody, conjugated with PE for fluorescence detection, offers high specificity and sensitivity towards human CD28 samples.With its ability to bind specifically to CD28 protein, this monoclonal antibody enables precise detection and quantification of CD28 expression in various cell types. The PE conjugation enhances visibility and allows for flow cytometry analysis, making it ideal for investigating immune responses, T cell activation, and immunotherapy research.

CD28 is a key receptor involved in T cell activation and immune signaling pathways, playing a pivotal role in modulating adaptive immune responses. Research focused on CD28 is critical for understanding immune system function, autoimmunity, transplant rejection, and immunotherapy development.By utilizing the Human CD28 Monoclonal Antibody PE Conjugated (CD28-2), researchers can delve deeper into the intricate mechanisms of immune regulation and T cell activation, paving the way for advancements in immunology, cancer immunotherapy, and autoimmune disease research.

Product Title:PE Anti-Human CD28 Antibody [CD28.2]
SKU:AGEL2021
Size:20 Tests, 100 Tests, 200 Tests
Clone No:CD28.2
Synonyms:PAS2;MNS;HGpMiX;GYPA;GPSAT;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P10747
Gene ID:940
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.

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