The Human CD273 (PD-L2) Monoclonal Antibody (PE Conjugated, 24F.10C12) is a cutting-edge tool for researchers studying the immune checkpoint protein PD-L2 in human samples. This monoclonal antibody, conjugated with phycoerythrin (PE), provides high specificity and sensitivity in flow cytometry and immunofluorescence applications, allowing for precise detection and analysis of PD-L2 expression on various cell types.PD-L2, also known as programmed death-ligand 2, is a key regulator of immune responses and tolerance. Its interaction with the PD-1 receptor on T cells plays a crucial role in modulating immune function and maintaining self-tolerance.
Dysregulation of the PD-L2/PD-1 pathway is implicated in conditions such as cancer, chronic infections, and autoimmune diseases, making PD-L2 an attractive target for therapeutic interventions.By utilizing the Human CD273 (PD-L2) Monoclonal Antibody (PE Conjugated, 24F.10C12), researchers can delve deeper into the mechanisms underlying immune tolerance and immune evasion in disease states. This antibody offers a valuable tool for investigating PD-L2 expression levels, distribution, and localization, ultimately contributing to the development of novel immunotherapies and precision medicine approaches targeting the PD-L2 pathway.
Product Title:
PE Anti-Human CD273/PD-L2 Antibody [24F.10C12]
SKU:
AGEL1861
Size:
20 Tests, 100 Tests, 200 Tests
Clone No:
24F.10C12
Synonyms:
B7DC; CD273; PDCD1L2; PDL2;
Host Species:
Mouse
Reactivity:
Human
Application:
FCM
Isotype:
Mouse IgG2a, κ
Isotype Control:
PE Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:
Liquid
Conjugation:
PE
Recommended Use:
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
Q9BQ51
Gene ID:
80380
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD273, known as B7-DC, is also called programmed death ligand 2 (PDL2). This ligand is a 25 kD type I transmembrane protein and a member of B7 family within the immunoglobulin receptor superfamily and is expressed on a subset of dendritic cells, liver and a small subset of macrophages as well as a few transformed cell lines. CD273 has been reported to be stimulatory on dendritic cells when cross-linked and to inhibit T cell activation upon engaging the PD-1 receptor. CD273 has also been reported to bind to an alternative receptor and to mediate T cell activation through such non-PD1 mediated interactions.
![PE Anti-Human CD273/PD-L2 Antibody [24F.10C12] (AGEL1861)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/1280x1280/products/22392/605495/pe-anti-human-cd273pd-l2-antibody-24f.10c12-agel1861__35672.1707495066.jpg?c=2&imbypass=on "PE Anti-Human CD273/PD-L2 Antibody [24F.10C12] (AGEL1861)")
![APC Anti-Human CD273/PD-L2 Antibody [24F.10C12] (AGEL1862)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/22393/606140/apc-anti-human-cd273pd-l2-antibody-24f.10c12-agel1862__59829.1707497092.jpg?c=2 "APC Anti-Human CD273/PD-L2 Antibody [24F.10C12] (AGEL1862)")
