Human CD244 Recombinant Protein (RPPB5874)
- SKU:
- RPPB5874
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9BZW8
- Research Area:
- CD Antigens
Description
| Product Name: | Human CD244 Recombinant Protein |
| Product Code: | RPPB5874 |
| Size: | 10µg |
| Species: | Human |
| Target: | CD244 |
| Synonyms: | Natural killer cell receptor 2B4, NK cell activation-inducing ligand, NAIL, NK cell type I receptor protein 2B4, NKR2B4, h2B4, CD244, 2B4, Nmrk, SLAMF4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CD244 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer, pH8.0 and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHGKGCQG SADHVVSISG VPLQLQPNSI QTKVDSIAWK KLLPSQNGFH HILKWENGSL PSNTSNDRFS FIVKNLSLLI KAAQQQDSGL YCLEVTSISG KVQTATFQVF VFDKVEKPRL QGQGKILDRG RCQVALSCLV SRDGNVSYAW YRGSKLIQTA GNLTYLDEEV DINGTHTYTC NVSNPVSWES HTLNLTQDCQ NAHQEFRFWP |
Cluster of Differentiation 244 (CD244/Natural Killer Cell Receptor 2B4) contains 2 Ig-like (immunoglobulin-like) domains. CD244 is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) which mediate non-major histocompatibility complex (MHC) restricted killing. NK-cell and target cells interaction via the CD244 receptor is believed to modulate NK-cell cytolytic activity. CD244 molecules function in eosinophil adhesion and chemotaxis, and have a role in the pathophysiology of allergic rhinitis (AR).
CD244 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 230 amino acids (19-224 a.a) and having a molecular mass of 25.5kDa.CD244 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CD244: Modulate other receptor-ligand interactions to enhance leukocyte activation. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q23.3 Cellular Component: plasma membrane; integral to membrane; external side of plasma membrane Molecular Function:protein binding; receptor activity Biological Process: signal transduction; blood coagulation; leukocyte migration Disease: Rheumatoid Arthritis |
| NCBI Summary: | This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] |
| UniProt Code: | Q9BZW8 |
| NCBI GenInfo Identifier: | 47605541 |
| NCBI Gene ID: | 51744 |
| NCBI Accession: | Q9BZW8.2 |
| UniProt Related Accession: | Q9BZW8 |
| Molecular Weight: | |
| NCBI Full Name: | |
| NCBI Synonym Full Names: | CD244 molecule |
| NCBI Official Symbol: | CD244�� |
| NCBI Official Synonym Symbols: | 2B4; NAIL; Nmrk; NKR2B4; SLAMF4�� |
| NCBI Protein Information: | natural killer cell receptor 2B4 |
| UniProt Protein Name: | Natural killer cell receptor 2B4 |
| UniProt Synonym Protein Names: | NK cell activation-inducing ligand; NAIL; NK cell type I receptor protein 2B4; NKR2B4; h2B4; SLAM family member 4; SLAMF4; Signaling lymphocytic activation molecule 4; CD_antigen: CD244 |
| UniProt Gene Name: | CD244�� |
| UniProt Entry Name: | CD244_HUMAN |
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