Human CD244 Recombinant Protein (RPPB3046)
- SKU:
- RPPB3046
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9BZW8
- Research Area:
- CD Antigens
Description
| Product Name: | Human CD244 Recombinant Protein |
| Product Code: | RPPB3046 |
| Size: | 10µg |
| Species: | Human |
| Target: | CD244 |
| Synonyms: | Natural killer cell receptor 2B4, NK cell activation-inducing ligand, NAIL, NK cell type I receptor protein 2B4, NKR2B4, h2B4, SLAM family member 4, SLAMF4, Signaling lymphocytic activation molecule 4, CD244, 2B4. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CD244 protein solution (1.0mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADLGKGCQGS ADHVVSISGV PLQLQPNSIQ TKVDSIAWKK LLPSQNGFHH ILKWENGSLP SNTSNDRFSF IVKNLSLLIK AAQQQDSGLY CLEVTSISGK VQTATFQVFV FDKVEKPRLQ GQGKILDRGR CQVALSCLVS RDGNVSYAWY RGSKLIQTAG NLTYLDEEVD INGTHTYTCN VSNPVSWESH TLNLTQDCQN AHQEFRFWPL EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH |
Cluster of Differentiation 244 (CD244/Natural Killer Cell Receptor 2B4) contains 2 Ig-like (immunoglobulin-like) domains. CD244 is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) which mediate non-major histocompatibility complex (MHC) restricted killing. NK-cell and target cells interaction via the CD244 receptor is believed to modulate NK-cell cytolytic activity. CD244 molecules function in eosinophil adhesion and chemotaxis, and have a role in the pathophysiology of allergic rhinitis (AR).
CD244 Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 448 amino acids (19-224a.a.) and having a molecular mass of 50.2kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa). CD244 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CD244: Modulate other receptor-ligand interactions to enhance leukocyte activation. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q23.3 Cellular Component: plasma membrane; integral to membrane; external side of plasma membrane Molecular Function:protein binding; receptor activity Biological Process: signal transduction; blood coagulation; leukocyte migration Disease: Rheumatoid Arthritis |
| NCBI Summary: | This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] |
| UniProt Code: | Q9BZW8 |
| NCBI GenInfo Identifier: | 47605541 |
| NCBI Gene ID: | 51744 |
| NCBI Accession: | Q9BZW8.2 |
| UniProt Related Accession: | Q9BZW8 |
| Molecular Weight: | |
| NCBI Full Name: | |
| NCBI Synonym Full Names: | CD244 molecule |
| NCBI Official Symbol: | CD244�� |
| NCBI Official Synonym Symbols: | 2B4; NAIL; Nmrk; NKR2B4; SLAMF4�� |
| NCBI Protein Information: | natural killer cell receptor 2B4 |
| UniProt Protein Name: | Natural killer cell receptor 2B4 |
| UniProt Synonym Protein Names: | NK cell activation-inducing ligand; NAIL; NK cell type I receptor protein 2B4; NKR2B4; h2B4; SLAM family member 4; SLAMF4; Signaling lymphocytic activation molecule 4; CD_antigen: CD244 |
| UniProt Gene Name: | CD244�� |
| UniProt Entry Name: | CD244_HUMAN |
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